{"refrec":{"BRefID":304588,"RR":"<b>Dal Piaz, F.; Bader, A.; Malafronte, N.; D'Ambola, M.; Petrone, A.M.; Porta, A.; Ben Hadda, T.; De Tommasi, N.; Bisio, A.; Severino, L.</b> (2018). Phytochemistry of compounds isolated from the leaf-surface extract of <i>Psiadia punctulata</i> (DC.) Vatke growing in Saudi Arabia. <i>Phytochemistry 155</i>: 191-202. <a href=\"https://dx.doi.org/10.1016/j.phytochem.2018.08.003\" target=\"_blank\">https://dx.doi.org/10.1016/j.phytochem.2018.08.003</a>","BEntID":296883,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Phytochemistry 155</i>: 191-202. <a href=\"https://dx.doi.org/10.1016/j.phytochem.2018.08.003\" target=\"_blank\">https://dx.doi.org/10.1016/j.phytochem.2018.08.003</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Dal Piaz, F.; Bader, A.; Malafronte, N.; D'Ambola, M.; Petrone, A.M.; Porta, A.; Ben Hadda, T.; De Tommasi, N.; Bisio, A.; Severino, L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Dal Piaz, F. <i>et al.</i>","Englishabstract":"The surface extract of an accession of <i>Psiadia punctulata</i> (DC.) Vatke (Asteraceae) growing in Saudi Arabia was investigated for its phytochemicalcomposition. A bio-guided investigation of the extract led to the isolation of thirteen ent-kaurane and trachylobane diterpenes and seventeen compounds previously described, including nine flavonoids and eight diterpenes. Three flavonoids and one <i>ent</i>-kaurane diterpene showed antimicrobial activity with MIC100 values ranging from 25 to 150 μg/ml. The extract showed antibacterial activity against <i>Staphylococcus aureus</i> (MIC<sub>100</sub> = 180 μg/ml) and antifungal activity against <i>Candida albicans</i> (MIC<sub>0</sub> = 130 μg/ml). The isolated 3′,4′,5,7-tetramethoxyflavone, at a concentration of 40 μg/ml, displayed the ability to reduce biofilm formation of <i>S. aureus</i> and <i>C. albicans</i> by 50% and 90% respectively.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Phytochemistry of compounds isolated from the leaf-surface extract of <i>Psiadia punctulata</i> (DC.) 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