{"refrec":{"BRefID":307904,"RR":"<b>Yaacob, E.N.; De Geest, B.G.; Goethals, J.; Bajek, A.; Dierckens, K.; Bossier, P.; Vanrompay, D.</b> (2018). Recombinant ferritin-H induces immunosuppression in European sea bass larvae (<i>Dicentrarchus labrax</i>) rather than immunostimulation and protection against a <i>Vibrio anguillarum</i> infection. <i>Vet. Immunol. Immunopathol. 204</i>: 19-27. <a href=\"https://dx.doi.org/10.1016/j.vetimm.2018.09.001\" target=\"_blank\">https://dx.doi.org/10.1016/j.vetimm.2018.09.001</a>","BEntID":300230,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Vet. Immunol. Immunopathol. 204</i>: 19-27. <a href=\"https://dx.doi.org/10.1016/j.vetimm.2018.09.001\" target=\"_blank\">https://dx.doi.org/10.1016/j.vetimm.2018.09.001</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yaacob, E.N.; De Geest, B.G.; Goethals, J.; Bajek, A.; Dierckens, K.; Bossier, P.; Vanrompay, D.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yaacob, E.N. <i>et al.</i>","Englishabstract":"<i>Vibrio anguillarum</i> causes high mortality in European sea bass (<i>Dicentrarchus labrax</i>) larviculture. In this study, we evaluated if the recombinant sea bass ferritin-H could stimulate the innate immune system of gnotobiotic European sea bass larvae resulting in protection against a <i>V. anguillarum</i> challenge. We also evaluated the effect of a <i>V. anguillarum</i> infection on the transcription of immune-related genes in gnotobiotic European sea bass larvae. Recombinant sea bass ferritin-H was produced, encapsulated in calcium alginate microparticles and orally delivered to sea bass larvae at seven days after hatching. Our results showed <i>V. anguillarum</i> caused an acute infection, resulting in high mortality. The infection significantly upregulated the expression of <i>tlr3, tlr5, cas1, il1β, tnfα, mif, il10, cc1, cxcl8</i> at 18, 24 and 36 h post infection, but not of the chemokine receptor genes cxcr4 and ccr9. There was no protective effect of ferritin-H. Remarkably, ferritin-H caused significantly higher transcript levels for <i>cxcr4</i> and <i>ccr9</i>. Sea bass ferritin-H was more likely involved in immune-suppression and results point in the direction of a negative regulation of CXCR4 resulting in inhibition of cell proliferation, differentiation and migration which is detrimental to innate immunity and might explain the non-protective effect of ferritin-H in fish larvae.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Recombinant ferritin-H induces immunosuppression in European sea bass larvae (<i>Dicentrarchus labrax</i>) rather than immunostimulation and protection against a <i>Vibrio anguillarum</i> infection","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-18 01:32:08.848620","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Sea bass; Larvae; Gnotobiotic; Vibrio anguillarum; Ferritin; Innateimmunity","OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2021-09-08","DateCreate":"2019-03-13","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000450378800003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.vetimm.2018.09.001"},"refs":null,"anarec":{"AnaID":307904,"PubliDate":2018,"Pagination":"19-27","XtraPublOfAnaID":null,"ISBN":null,"Volume":"204","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44062,"SerRR":"Veterinary Immunology and Immunopathology. 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