{"refrec":{"BRefID":307912,"RR":"<b>Dubos, M.-P.; Zels, S.; Schwartz, J.; Pasquier, J.; Schoofs, L.; Favrel, P.</b> (2018). Characterization of a tachykinin signalling system in the bivalve mollusc <i>Crassostrea gigas</i>. <i>Gen. Comp. Endocrinol. 266</i>: 110-118. <a href=\"https://dx.doi.org/10.1016/j.ygcen.2018.05.003\" target=\"_blank\">https://dx.doi.org/10.1016/j.ygcen.2018.05.003</a>","BEntID":300238,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Gen. Comp. Endocrinol. 266</i>: 110-118. <a href=\"https://dx.doi.org/10.1016/j.ygcen.2018.05.003\" target=\"_blank\">https://dx.doi.org/10.1016/j.ygcen.2018.05.003</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Dubos, M.-P.; Zels, S.; Schwartz, J.; Pasquier, J.; Schoofs, L.; Favrel, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Dubos, M.-P. <i>et al.</i>","Englishabstract":"Although tachykinin-like neuropeptides have been identified in molluscs more than two decades ago, knowledge on their function and signalling has so far remained largely elusive. We developed a cell-based assay to address the functionality of the tachykinin G-protein coupled receptor (Cragi-TKR) in the oyster <i>Crassostrea gigas</i>. The oyster tachykinin neuropeptides that are derived from the tachykinin precursor gene Cragi-TK activate the Cragi-TKR in nanomolar concentrations. Receptor activation is sensitive to Ala-substitution of critical Cragi-TK amino acid residues. The Cragi-TKR gene is expressed in a variety of tissues, albeit at higher levels in the visceral ganglia (VG) of the nervous system. Fluctuations of Cragi-TKR expression is in line with a role for TK signalling in <i>C. gigas</i> reproduction. The expression level of the Cragi-TK gene in the VG depends on the nutritional status of the oyster, suggesting a role for TK signalling in the complex regulation of feeding in <i>C. gigas</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Characterization of a tachykinin signalling system in the bivalve mollusc <i>Crassostrea gigas</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:32:30.414590","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Mollusc; Neuropeptide; Tachykinin signalling; Feeding","OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2020-06-26","DateCreate":"2019-03-13","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000442707700012","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.ygcen.2018.05.003"},"refs":null,"anarec":{"AnaID":307912,"PubliDate":2018,"Pagination":"110-118","XtraPublOfAnaID":null,"ISBN":null,"Volume":"266","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42729,"SerRR":"General and Comparative Endocrinology. 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