{"refrec":{"BRefID":307951,"RR":"<b>Kvetkina, A.N.; Leychenko, E.V.; Yurchenko, E.A.; Pislyagin, E.A.; Peigneur, S.; Tytgat, Y.; Isaeva, M.P.; Aminin, D.L.; Kozlovskaya, E.P.</b> (2018). A new Iq-peptide of the Kunitz type from the <i>Heteractis magnifica</i> sea anemone exhibits neuroprotective activity in a model of Alzheimer's disease. <i>Russian Journal of Bioorganic Chemistry 44(4)</i>: 416-423. <a href=\"https://dx.doi.org/10.1134/S106816201804012X\" target=\"_blank\">https://dx.doi.org/10.1134/S106816201804012X</a>","BEntID":300277,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Russian Journal of Bioorganic Chemistry 44(4)</i>: 416-423. <a href=\"https://dx.doi.org/10.1134/S106816201804012X\" target=\"_blank\">https://dx.doi.org/10.1134/S106816201804012X</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kvetkina, A.N.; Leychenko, E.V.; Yurchenko, E.A.; Pislyagin, E.A.; Peigneur, S.; Tytgat, Y.; Isaeva, M.P.; Aminin, D.L.; Kozlovskaya, E.P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kvetkina, A.N. <i>et al.</i>","Englishabstract":"The HMIQ3c1 recombinant peptide (6434 Da), the Kunitz-type protease inhibitor, which belonged to the new group of the IQ-peptides from the <em class=\"EmphasisTypeItalic \">Heteractis magnifica</em> sea anemone was prepared. The inhibitory constant of trypsin by this peptide proved to be 5.0 × 10<sup>–8</sup> M. rHMIQ3c1 was shown to have no interaction with eight isoforms of Kv1 channels. This peptide exhibited neuroprotective activity in a concentration of 10 μM, and the peptide increased the viability of cells of the Neuro2a murine neuroblastoma by 39.4 ± 6.6% in the presence of β-amyloid. 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