{"refrec":{"BRefID":307981,"RR":"<b>Yanez-Guerra, L.A.; Delroisse, J.; Barreiro-Iglesias, A.; Slade, S.E.; Scrivens, J.H.; Elphick, M.R.</b> (2018). Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome. <i>NPG Scientific Reports 8</i>: 7220. <a href=\"https://dx.doi.org/10.1038/s41598-018-25606-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-018-25606-2</a>","BEntID":300307,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 8</i>: 7220. <a href=\"https://dx.doi.org/10.1038/s41598-018-25606-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-018-25606-2</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yanez-Guerra, L.A.; Delroisse, J.; Barreiro-Iglesias, A.; Slade, S.E.; Scrivens, J.H.; Elphick, M.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yanez-Guerra, L.A. <i>et al.</i>","Englishabstract":"Neuropeptides are diverse and evolutionarily ancient regulators of physiological/behavioural processes in animals. Here we have investigated the evolution and comparative physiology of luqin-type neuropeptide signalling, which has been characterised previously in protostomian invertebrates. Phylogenetic analysis indicates that luqin-type receptors and tachykinin-type receptors are paralogous and probably originated in a common ancestor of the Bilateria. In the deuterostomian lineage, luqin-type signalling has been lost in chordates but interestingly it has been retained in ambulacrarians. Therefore, here we characterised luqin-type signalling for the first time in an ambulacrarian – the starfish <i>Asterias rubens</i> (phylum Echinodermata). A luqin-like neuropeptide with a C-terminal RWamide motif (ArLQ; EEKTRFPKFMRW-NH<sub>2</sub>) was identified as the ligand for two luqin-type receptors in <i>A</i>. <i>rubens</i>, ArLQR1 and ArLQR2. Furthermore, analysis of the expression of the ArLQ precursor using mRNA <i>in situ</i> hybridisation revealed expression in the nervous system, digestive system and locomotory organs (tube feet) and <i>in vitro</i> pharmacology revealed that ArLQ causes dose-dependent relaxation of tube feet. Accordingly, previous studies have revealed that luqin-type signalling regulates feeding and locomotor activity in protostomes. In conclusion, our phylogenetic analysis combined with characterisation of luqin-type signalling in a deuterostome has provided new insights into neuropeptide evolution and function in the animal kingdom.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-21 01:32:45.909504","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2019-03-19","DateCreate":"2019-03-13","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000431626700003","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-018-25606-2"},"refs":null,"anarec":{"AnaID":307981,"PubliDate":2018,"Pagination":"7220","XtraPublOfAnaID":null,"ISBN":null,"Volume":"8","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). Nature Publishing Group: London.  ISSN 2045-2322; e-ISSN 2045-2322","StandardTitleSer":"Scientific Reports (Nature Publishing Group)","ISSN":"2045-2322","AbbrevSer":"NPG Scientific Reports","StandardTitleMon":null,"StartPage":14,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Yanez-Guerra","Firstname":"Luis","Initials":"L.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":368795,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Delroisse","Firstname":"Jérôme","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":368796,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-9233-6470","PersID":28258,"InsID":null},{"AutName":"Barreiro-Iglesias","Firstname":"Antón","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":368798,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Slade","Firstname":"Susan","Initials":"S.E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":319228,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Scrivens","Firstname":"James","Initials":"J.H.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":319229,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Elphick","Firstname":"Maurice","Initials":"M.R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":300307,"AutID":319230,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":326424,"LibID":36,"BRefID":307981,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"326424","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"OMA - 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