{"refrec":{"BRefID":310163,"RR":"<b>Robinson, S.D.; Undheim, E.A.B.; Ueberheide, B.; King, G.F.</b> (2017). Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery. <i>Expert Review of Proteomics 14(10)</i>: 931-939. <a href=\"https://dx.doi.org/10.1080/14789450.2017.1377613\" target=\"_blank\">https://dx.doi.org/10.1080/14789450.2017.1377613</a>","BEntID":302494,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Expert Review of Proteomics 14(10)</i>: 931-939. <a href=\"https://dx.doi.org/10.1080/14789450.2017.1377613\" target=\"_blank\">https://dx.doi.org/10.1080/14789450.2017.1377613</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Robinson, S.D.; Undheim, E.A.B.; Ueberheide, B.; King, G.F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Robinson, S.D. <i>et al.</i>","Englishabstract":"Introduction: Animal venoms are complex chemical arsenals. Most venoms are rich in bioactive peptides with proven potential as research tools, drug leads and drugs.Areas covered: We review recent advances in venom-peptide discovery, particularly the adoption of combined transcriptomic/proteomic approaches for the exploration of venom composition.Expert commentary: Advances in transcriptomics and proteomics have dramatically altered the manner and rate of venom-peptide discovery. The increasing trend towards a toxin-driven approach, as opposed to traditional target-based screening of venoms, is likely to expedite the discovery of venom-peptides with novel structures and new and unanticipated mechanisms of action. At the same time, these advances will drive the development of higher-throughput approaches for target identification. Taken together, these approaches should enhance our understanding of the natural ecological function of venom peptides and increase the rate of identification of novel venom-derived pharmacological tools, drug leads and drugs.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Venom, peptide, toxin, mass spectrometry, proteome, transcriptome","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2019-04-03","DateCreate":"2019-04-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000413850000009","VABBcode":null,"OpenAcc":0,"DOI":"10.1080/14789450.2017.1377613"},"refs":null,"anarec":{"AnaID":310163,"PubliDate":2017,"Pagination":"931-939","XtraPublOfAnaID":null,"ISBN":null,"Volume":"14","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":268069,"SerRR":"Expert Review of Proteomics. 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