{"refrec":{"BRefID":310402,"RR":"<b>Styfhals, R.; Seuntjens, E.; Simakov, O.; Sanges, R.; Fiorito, G.</b> (2019). <i>In silico</i> identification and expression of protocadherin gene family in <i>Octopus vulgaris</i>. <i>Frontiers in Physiology 9</i>: 1905. <a href=\"https://dx.doi.org/10.3389/fphys.2018.01905\" target=\"_blank\">https://dx.doi.org/10.3389/fphys.2018.01905</a>","BEntID":302733,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Frontiers in Physiology 9</i>: 1905. <a href=\"https://dx.doi.org/10.3389/fphys.2018.01905\" target=\"_blank\">https://dx.doi.org/10.3389/fphys.2018.01905</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Styfhals, R.; Seuntjens, E.; Simakov, O.; Sanges, R.; Fiorito, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Styfhals, R. <i>et al.</i>","Englishabstract":"Connecting millions of neurons to create a functional neural circuit is a daunting challenge. Vertebrates developed a molecular system at the cell membrane to allow neurons to recognize each other by distinguishing self from non-self through homophilic protocadherin interactions. In mammals, the protocadherin gene family counts about 50 different genes. By hetero-multimerization, protocadherins are capable of generating an impressive number of molecular interfaces. Surprisingly, in the California two-spot octopus, <i>Octopus bimaculoides</i>, an invertebrate belonging to the Phylum Mollusca, over 160 protocadherins (PCDHs) have been identified. Here we briefly discuss the role of PCDHs in neural wiring and conduct a comparative study of the protocadherin gene family in two closely related octopus species, <i>Octopus vulgaris</i> and <i>O. bimaculoides</i>. A first glance at the expression patterns of protocadherins in <i>O. vulgaris</i> is also provided. 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