{"refrec":{"BRefID":310429,"RR":"<b>Russo, M.T.; Vitale, L.; Entrambasaguas, L.; Anestis, K.; Fattorini, N.; Romano, F.; Minucci, C.; De Luca, P.; Biffali, E.; Vyverman, W.; Sanges, R.; Montresor, M.; Ferrante, M.I.</b> (2018). MRP3 is a sex determining gene in the diatom <i>Pseudo-nitzschia multistriata</i>. <i>Nature Comm. 9</i>: 10. <a href=\"https://dx.doi.org/10.1038/s41467-018-07496-0\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-018-07496-0</a>","BEntID":302760,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 9</i>: 10. <a href=\"https://dx.doi.org/10.1038/s41467-018-07496-0\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-018-07496-0</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Russo, M.T.; Vitale, L.; Entrambasaguas, L.; Anestis, K.; Fattorini, N.; Romano, F.; Minucci, C.; De Luca, P.; Biffali, E.; Vyverman, W.; Sanges, R.; Montresor, M.; Ferrante, M.I.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Russo, M.T. <i>et al.</i>","Englishabstract":"A broad diversity of sex-determining systems has evolved in eukaryotes. However, information on the mechanisms of sex determination for unicellular microalgae is limited, including for diatoms, key-players of ocean food webs. Here we report the identification of a mating type (MT) determining gene for the diatom <i>Pseudo-nitzschia multistriata</i>. By comparing the expression profile of the two MTs, we find five MT-biased genes, of which one, <i>MRP3</i>, is expressed exclusively in MT+ strains in a monoallelic manner. A short tandem repeat of specific length in the region upstream of <i>MRP3</i> is consistently present in MT+ and absent in MT− strains. <i>MRP3</i> overexpression in an MT− strain induces sex reversal: the transgenic MT− can mate with another MT− strain and displays altered regulation of the other MT-biased genes, indicating that they lie downstream. Our data show that a relatively simple genetic program is involved in defining the MT in <i>P. multistriata</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"MRP3 is a sex determining gene in the diatom <i>Pseudo-nitzschia multistriata</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-08 01:33:32.669444","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2019-04-23","DateCreate":"2019-04-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000451433800020","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-018-07496-0"},"refs":null,"anarec":{"AnaID":310429,"PubliDate":2018,"Pagination":"10","XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. 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