{"refrec":{"BRefID":310498,"RR":"<b>Degueldre, M.; Verdenaud, M.; Legarda, G.; Minambres, R.; Zuniga, S.; Leblanc, M.; Gilles, N.; Ducancel, F.; De Pauw, E.; Quinton, L.</b> (2017). Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four <i>Conus</i> species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics. <i>Toxicon 130</i>: 116-125. <a href=\"https://dx.doi.org/10.1016/j.toxicon.2017.02.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.toxicon.2017.02.014</a>","BEntID":302829,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Toxicon 130</i>: 116-125. <a href=\"https://dx.doi.org/10.1016/j.toxicon.2017.02.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.toxicon.2017.02.014</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Degueldre, M.; Verdenaud, M.; Legarda, G.; Minambres, R.; Zuniga, S.; Leblanc, M.; Gilles, N.; Ducancel, F.; De Pauw, E.; Quinton, L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Degueldre, M. <i>et al.</i>","Englishabstract":"Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from <i>Conus</i> venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four <i>Conus</i> species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Venomics; Proteomics; Transcriptomics; Bioinformatics; Cone snail;Diversity","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2019-04-19","DateCreate":"2019-04-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000399510700015","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.toxicon.2017.02.014"},"refs":null,"anarec":{"AnaID":310498,"PubliDate":2017,"Pagination":"116-125","XtraPublOfAnaID":null,"ISBN":null,"Volume":"130","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43961,"SerRR":"Toxicon. Elsevier: Oxford.  ISSN 0041-0101; e-ISSN 1879-3150","StandardTitleSer":"Toxicon","ISSN":"0041-0101","AbbrevSer":"Toxicon","StandardTitleMon":null,"StartPage":116,"Pages":10,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Degueldre","Firstname":"Michel","Initials":"M.","Affiliation":"Laboratory of Mass Spectrometry, MolSys, ULg","Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374275,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MSLAB","InsFSN":"Université de Liège; Faculté des Sciences; Département de Chimie; Laboratoire de Spectrométrie de Masse","ORCID":null,"PersID":37644,"InsID":1905},{"AutName":"Verdenaud","Firstname":"Marion","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374276,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Legarda","Firstname":"Garikoitz","Initials":"G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374277,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Minambres","Firstname":"Rebeca","Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374278,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Zuniga","Firstname":"Sheila","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374279,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Leblanc","Firstname":"Mathieu","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374280,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Gilles","Firstname":"Nicolas","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":318891,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ducancel","Firstname":"Frederic","Initials":"F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374282,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"De Pauw","Firstname":"Edwin","Initials":"E.","Affiliation":"Laboratory of Mass Spectrometry, MolSys, ULg","Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374283,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MSLAB","InsFSN":"Université de Liège; Faculté des Sciences; Département de Chimie; Laboratoire de Spectrométrie de Masse","ORCID":"0000-0003-3475-1315","PersID":3058,"InsID":1905},{"AutName":"Quinton","Firstname":"Loïc","Initials":"L.","Affiliation":"Laboratory of Mass Spectrometry, MolSys, ULg","Discriminator":null,"CorporateFlag":0,"BEntID":302829,"AutID":374284,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MSLAB","InsFSN":"Université de Liège; Faculté des Sciences; Département de Chimie; Laboratoire de Spectrométrie de Masse","ORCID":null,"PersID":31415,"InsID":1905}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":328352,"LibID":36,"BRefID":310498,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"328352","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Elsevier","City":"Oxford"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Conus"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":302829,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":302829,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.toxicon.2017.02.014","externalID":"10.1016/j.toxicon.2017.02.014","URLTypeCode":"DOI","URLID":75750,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Conus","AphiaID":137813,"TaxtID":39253}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Conus","DutchTerm":null,"AphiaID":137813,"TaxtID":39253}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2019-04-17 22:29:13.977000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2019-04-19 08:58:09.630000","timezone_type":3,"timezone":"Europe/Brussels"}}}