{"refrec":{"BRefID":311414,"RR":"<b>Hernandez, A.L.; Dortu, F.; Veenstra, T.; Ciaurriz, P.; Casquel, R.; Cornago, I.; Horsten, H.V.; Tellechea, E.; Maigler, M.V.; Fernández, F.; Holgado, M.</b> (2019). Automated chemical sensing unit integration for parallel optical interrogation. <i>Sensors 19(4)</i>: 878. <a href=\"https://dx.doi.org/10.3390/s19040878\" target=\"_blank\">https://dx.doi.org/10.3390/s19040878</a>","BEntID":303776,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Sensors 19(4)</i>: 878. <a href=\"https://dx.doi.org/10.3390/s19040878\" target=\"_blank\">https://dx.doi.org/10.3390/s19040878</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Hernandez, A.L.; Dortu, F.; Veenstra, T.; Ciaurriz, P.; Casquel, R.; Cornago, I.; Horsten, H.V.; Tellechea, E.; Maigler, M.V.; Fernández, F.; Holgado, M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Hernandez, A.L. <i>et al.</i>","Englishabstract":"We report the integration of an automated chemical optical sensing unit for the parallel interrogation of 12 BICELLs in a sensing chip. The work was accomplished under the European Project Enviguard (FP7-OCEAN-2013-614057) with the aim of demonstrating an optical nano-biosensing unit for the in-situ detection of various chemical pollutants simultaneously in oceanic waters. In this context, we designed an optical sensing chip based on resonant nanopillars (R-NPs) transducers organized in a layout of twelve biophotonic sensing cells (BICELLs). The sensing chip is interrogated in reflection with a 12-channels optical spectrometer equipped with an embedded computer-on-chip performing image processing for the simultaneous acquisition and analysis (resonant mode fitting) of the 12 spectra. A microfluidic chip and an automated flow control system composed of four pumps and a multi-path micro-valve makes it possible to drive different complex protocols. A rack was designed ad-hoc for the integration of all the modules. As a proof of concept, fluids of different refractive index (RI) were flowed in the system in order to measure the time response (sensogram) of the R-NPs under optical reflectance, and assess the sensors’ bulk sensitivity (285.9 ± 16.4 nm/RIU) and Limit of Detection (LoD) (2.95 × 10<sup>−6</sup> RIUS). The real-time response under continuous flow of a sensor chip based on R-NP is showed for the first time, obtaining 12 sensograms simultaneously, featuring the unit as a potential excellent multiplexed detection system. These results indicate the high potential of the developed chemical sensing unit to be used for in-situ, multiplex and automatic optical biosensing.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Automated chemical sensing unit integration for parallel optical interrogation","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"optical sensor; sensing; resonant nanopillars; parallel detection;microfluidics; automatic system","OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2024-04-16","DateCreate":"2019-05-28","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000460829200129","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/s19040878"},"refs":null,"anarec":{"AnaID":311414,"PubliDate":2019,"Pagination":"878","XtraPublOfAnaID":null,"ISBN":null,"Volume":"19","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":240560,"SerRR":"Sensors. 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