Document of bibliographic reference 312352
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- Elucidation of spirodactylone, a polycyclic alkaloid from the sponge Dactylia sp., and nonenzymatic generation from the co-metabolite Denigrin B
- Abstract
- Spirodactylone (1), a hexacyclic indolizidone alkaloid possessing a novel spiro ring system, was isolated from the marine sponge Dactylia sp. The structure was elucidated by extensive spectroscopic methods including application of the LR-HSQMBC NMR pulse sequence. Oxidative cyclization of denigrin B (2), an aryl-substituted 2-oxo-pyrroline derivative that was also isolated from the sponge extract, provided material identical to spirodactylone (1). This confirmed the assigned structure and provides insight into the probable biogenesis of 1.
- WebOfScience code
- https://www.webofscience.com/wos/woscc/full-record/WOS:000473116000075
- Bibliographic citation
- Kang, U.; Caldwell, D.R.; Cartner, L.K.; Wang, D.; Kim, C.-K.; Tian, X.; Bokesch, H.R.; Henrich, C.J.; Woldemichael, G.M.; Schnermann, M.J.; Gustafson, K.R. (2019). Elucidation of spirodactylone, a polycyclic alkaloid from the sponge Dactylia sp., and nonenzymatic generation from the co-metabolite Denigrin B. Organic Letters 21(12): 4750-4753. https://dx.doi.org/10.1021/acs.orglett.9b01636
- Topic
- Marine
- Is peer reviewed
- true
Authors
- author
-
- Name
- Unwoo Kang
- author
-
- Name
- Donald Caldwell
- author
-
- Name
- Laura Cartner
- author
-
- Name
- Dongdong Wang
- Identifier
- https://orcid.org/0000-0002-0412-6386
- author
-
- Name
- Chang-Kwon Kim
- author
-
- Name
- Xiangrong Tian
- author
-
- Name
- Heidi Bokesch
- author
-
- Name
- Curtis Henrich
- author
-
- Name
- Girma Woldemichael
- author
-
- Name
- Martin Schnermann
- author
-
- Name
- Kirk Gustafson