{"refrec":{"BRefID":318004,"RR":"<b>Yonemitsu, M.A.; Giersch, R.M.; Polo-Prieto, M.; Hammel, M.; Simon, A.; Cremonte, F.; Avilés, F.T.; Merino-Véliz, N.; Burioli, E.A.V.; Muttray, A.F.; Sherry, J.; Reinisch, C.; Baldwin, S.A.; Goff, S.P.; Houssin, M.; Arriagada, G.; Vázquez, N.; Bierne, N.; Metzger, M.J.</b> (2019). A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe. <i>eLIFE 8</i>: e47788. <a href=\"https://dx.doi.org/10.7554/eLife.47788.001\" target=\"_blank\">https://dx.doi.org/10.7554/eLife.47788.001</a>","BEntID":311441,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>eLIFE 8</i>: e47788. <a href=\"https://dx.doi.org/10.7554/eLife.47788.001\" target=\"_blank\">https://dx.doi.org/10.7554/eLife.47788.001</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yonemitsu, M.A.; Giersch, R.M.; Polo-Prieto, M.; Hammel, M.; Simon, A.; Cremonte, F.; Avilés, F.T.; Merino-Véliz, N.; Burioli, E.A.V.; Muttray, A.F.; Sherry, J.; Reinisch, C.; Baldwin, S.A.; Goff, S.P.; Houssin, M.; Arriagada, G.; Vázquez, N.; Bierne, N.; Metzger, M.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yonemitsu, M.A. <i>et al.</i>","Englishabstract":"Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (<i>Mytilus chilensis</i> in South America and <i>M. edulis</i> in Europe). Sequencing alleles from four loci (two nuclear and two mitochondrial) provided evidence of transmissible cancer in both species. Phylogenetic analysis of cancer-associated alleles and analysis of diagnostic SNPs showed that cancers in both species likely arose in a third species of mussel (<i>M. trossulus</i>), but these cancer cells are independent from the previously identified transmissible cancer in <i>M. trossulus</i> from Canada. Unexpectedly, cancers from <i>M. chilensis</i> and <i>M. edulis</i. are nearly identical, showing that the same cancer lineage affects both. Thus, a single transmissible cancer lineage has crossed into two new host species and has been transferred across the Atlantic and Pacific Oceans and between the Northern and Southern hemispheres.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2019-11-20","DateCreate":"2019-11-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000495432900001","VABBcode":null,"OpenAcc":1,"DOI":"10.7554/eLife.47788.001"},"refs":null,"anarec":{"AnaID":318004,"PubliDate":2019,"Pagination":"e47788","XtraPublOfAnaID":null,"ISBN":null,"Volume":"8","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":240535,"SerRR":"eLIFE. eLife Sciences Publications: Cambridge.  e-ISSN 2050-084X","StandardTitleSer":"eLIFE","ISSN":null,"AbbrevSer":null,"StandardTitleMon":null,"StartPage":null,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Yonemitsu","Firstname":"Marisa","Initials":"M.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396186,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Giersch","Firstname":"Rachael","Initials":"R.M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396187,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Polo-Prieto","Firstname":"Maria","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396188,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Hammel","Firstname":"Maurine","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396189,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Simon","Firstname":"Alexis","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396190,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Cremonte","Firstname":"Florencia","Initials":"F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":36749,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Avilés","Firstname":"Fernando","Initials":"F.T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396191,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Merino-Véliz","Firstname":"Nicolás","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396192,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Burioli","Firstname":"Erika","Initials":"E.A.V.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396193,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Muttray","Firstname":"Annette","Initials":"A.F.","Affiliation":"SLR Consulting Canada Ltd, Vancouver, BC V6J 1V4, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":302937,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sherry","Firstname":"James","Initials":"J.","Affiliation":"Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":302930,"OrderNr":11,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Reinisch","Firstname":"Carol","Initials":"C.","Affiliation":"Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":302931,"OrderNr":12,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Baldwin","Firstname":"Susan","Initials":"S.A.","Affiliation":"Univ British Columbia, Chem & Biol Engn, Vancouver, BC V6T 1Z3, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":302933,"OrderNr":13,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Goff","Firstname":"Stephen","Initials":"S.P.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":323719,"OrderNr":14,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Houssin","Firstname":"Maryline","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396198,"OrderNr":15,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Arriagada","Firstname":"Gloria","Initials":"G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396199,"OrderNr":16,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vázquez","Firstname":"Nuria","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":396200,"OrderNr":17,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Bierne","Firstname":"Nicolas","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":391941,"OrderNr":18,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Metzger","Firstname":"Michael","Initials":"M.J.","Affiliation":"Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA.","Discriminator":null,"CorporateFlag":0,"BEntID":311441,"AutID":302926,"OrderNr":19,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":340400,"LibID":36,"BRefID":318004,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"340400","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"eLife Sciences Publications","City":"Cambridge"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Mytilus chilensis"},{"TaxTerm":"Mytilus edulis"},{"TaxTerm":"Mytilus trossulus"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":311441,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":311441,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.7554/eLife.47788.001","externalID":"10.7554/eLife.47788.001","URLTypeCode":"DOI","URLID":79626,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Mytilus chilensis [Chilean blue mussel]","AphiaID":397041,"TaxtID":23828},{"TaxTerm":"Mytilus edulis","AphiaID":140480,"TaxtID":25121},{"TaxTerm":"Mytilus trossulus [foolish mussel]","AphiaID":140482,"TaxtID":35886}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Mytilus chilensis","DutchTerm":null,"AphiaID":397041,"TaxtID":23828},{"TaxTerm":"Mytilus edulis","DutchTerm":"Mossel","AphiaID":140480,"TaxtID":25121},{"TaxTerm":"Mytilus trossulus","DutchTerm":null,"AphiaID":140482,"TaxtID":35886}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2019-11-20 08:46:12.247000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Chisala, Chilekwa, C.","updSesDate":{"date":"2019-11-20 08:46:12.247000","timezone_type":3,"timezone":"Europe/Brussels"}}}