{"refrec":{"BRefID":319586,"RR":"<b>Arnold, J.; Engelmann, J.C.; Schneider, N.; Bosserhoff, A.K.; Kuphal, S.</b> (2020). miR-488-5p and its role in melanoma. <i>Experimental and Molecular Pathology 112</i>: 104348. <a href=\"https://dx.doi.org/10.1016/j.yexmp.2019.104348\" target=\"_blank\">https://dx.doi.org/10.1016/j.yexmp.2019.104348</a>","BEntID":313025,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Experimental and Molecular Pathology 112</i>: 104348. <a href=\"https://dx.doi.org/10.1016/j.yexmp.2019.104348\" target=\"_blank\">https://dx.doi.org/10.1016/j.yexmp.2019.104348</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Arnold, J.; Engelmann, J.C.; Schneider, N.; Bosserhoff, A.K.; Kuphal, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Arnold, J. <i>et al.</i>","Englishabstract":"Due to their ability to regulate dozens to hundreds of target genes simultaneously and, therefore, influence several oncogenic pathways at the same time, microRNAs are a fascinating research object in melanoma. MicroRNAs have been identified as regulators of tumor proliferation, invasion and metastasis in melanoma.More precisely, it has been published that dysregulation of miR-488 contibutes to the progression of several cancer entities. However, the biological functions of miR-488, in special miR-488-5<i>p</i> in melanoma, remain unclear.This study showed the involvement of miR-488-5<i>p</i> in Wnt/β-catenin pathway and the function as a tumor suppressor. Transfection of miR-488-5<i>p</i> mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis.These data indicated that miR-488-5<i>p</i> acts as a tumor suppressor and is lost during melanoma development. 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