Document of bibliographic reference 321430

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Different macrophage type triggering as target of the action of biologically active substances from marine invertebrates

Abstract

Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrophage balance is a promising current trend in pharmacology. Marine invertebrates are a vast source of the variety of structurally diverse compounds with potent pharmacological activities. For years, a large number of studies concerning the immunomodulatory properties of the marine substances have been run with using some intracellular markers of immune stimulation or suppression irrespective of the possible application of marine compounds in reprogramming of macrophage activation, and only few reports clearly demonstrated the macrophage-polarizing activities of some marine compounds during the last decade. In this review, the data on the immunomodulating e ects of the extracts and pure compounds of a variety of chemical structure from species of different classes of marine invertebrates are described with focus on their potential in shifting M1/M2 macrophage balance towards M1 or M2 phenotype.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000513184600041

Bibliographic citation

Dolmatova, L.S.; Dolmatov, I.Y. (2020). Different macrophage type triggering as target of the action of biologically active substances from marine invertebrates. Mar. Drugs 18(1): 37. https://dx.doi.org/10.3390/md18010037

Is peer reviewed

true

Access rights

open access

Is accessible for free

true