{"refrec":{"BRefID":323121,"RR":"<b>Lago, J.H.G.; Macridachis, J.; Oliveira, M.; Brito, L.; Vizetto-Duarte, C.; Florindo, C.; Hendrickx, S.; Maes, L.; Morais, T.; Uemi, M.; Neto, L.; Dionísio, L.; Cortes, S.; Barreira, L.; Custodio, L.; Alberício, F.; Varela, J.</b> (2019). Report of <i>in vitro</i> antileishmanial properties of Iberian macroalgae. <i>Nat. Prod. Res. 33(12)</i>: 1778-1782. <a href=\"https://dx.doi.org/10.1080/14786419.2018.1434637\" target=\"_blank\">https://dx.doi.org/10.1080/14786419.2018.1434637</a>","BEntID":316592,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Nat. Prod. Res. 33(12)</i>: 1778-1782. <a href=\"https://dx.doi.org/10.1080/14786419.2018.1434637\" target=\"_blank\">https://dx.doi.org/10.1080/14786419.2018.1434637</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lago, J.H.G.; Macridachis, J.; Oliveira, M.; Brito, L.; Vizetto-Duarte, C.; Florindo, C.; Hendrickx, S.; Maes, L.; Morais, T.; Uemi, M.; Neto, L.; Dionísio, L.; Cortes, S.; Barreira, L.; Custodio, L.; Alberício, F.; Varela, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lago, J.H.G. <i>et al.</i>","Englishabstract":"Here is reported the anti <i>Leishmania infantum</i> activity of 48 hexane, CH<sub>2</sub>Cl<sub>2</sub> and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH<sub>2</sub>Cl<sub>2</sub> <i>Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis</i> and <i>Plocamium cartilagineum</i> extracts were active towards promastigotes (IC<sub>50</sub> 29.8–101.8&nbsp;μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of <i>C. baccata</i> and <i>C. barbata</i> were also active against intracellular amastigotes (IC<sub>50</sub> 5.1 and 6.8&nbsp;μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the <i>Cystoseira</i> extracts. 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