{"refrec":{"BRefID":323177,"RR":"<b>Lipson, V.V.; Pavlovska, T.L.; Svetlichnaya, N.V.; Poryvai, A.A.; Gorobets, N.Y.; Van der Eycken, E.V.; Konovalova, I.S.; Shiskina, S.V.; Borisov, A.V.; Musatov, V.I.; Mazepa, A.V.</b> (2019). Novel (2-amino-4-arylimidazolyl) propanoic acids and pyrrolo[1,2-<i>c</i>]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds. <i>Beilstein Journal of Organic Chemistry 15</i>: 1032-1045. <a href=\"https://dx.doi.org/10.3762/bjoc.15.101\" target=\"_blank\">https://dx.doi.org/10.3762/bjoc.15.101</a>","BEntID":316648,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Beilstein Journal of Organic Chemistry 15</i>: 1032-1045. <a href=\"https://dx.doi.org/10.3762/bjoc.15.101\" target=\"_blank\">https://dx.doi.org/10.3762/bjoc.15.101</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lipson, V.V.; Pavlovska, T.L.; Svetlichnaya, N.V.; Poryvai, A.A.; Gorobets, N.Y.; Van der Eycken, E.V.; Konovalova, I.S.; Shiskina, S.V.; Borisov, A.V.; Musatov, V.I.; Mazepa, A.V.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lipson, V.V. <i>et al.</i>","Englishabstract":"The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrum’s acid has selectively led to the corresponding Knoevenagel–Michael adducts containing a free amino group in the imidazole fragment. The adducts derived from Meldrum’s acid have been smoothly converted into 1,7-diaryl-3-amino-6,7-dihydro-5<i>H</i>-pyrrolo[1,2-<i>c</i>]imidazol-5-ones and 3-(2-amino-4-aryl-1<i>H</i>-imidazol-5-yl)-3-arylpropanoic acids. The interaction of 2-amino-4-arylimidazoles with aromatic aldehydes or isatins and acyclic methylene active compounds has led to the formation of pyrrolo[1,2-<i>c</i>]imidazole-6-carbonitriles, pyrrolo[1,2-<i>с</i>]imidazole-6-carboxylates and spiro[indoline-3,7'-pyrrolo[1,2-<i>c</i>]imidazoles], which can be considered as the analogues of both 3,3’-spirooxindole and 2-aminoimidazole marine sponge alkaloids.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Novel (2-amino-4-arylimidazolyl) propanoic acids and pyrrolo[1,2-<i>c</i>]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"2-amino-4-arylimidazole; (2-amino-4-arylimidazolyl)propanoic acid;isatin; Meldrum's acid; multicomponent 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