{"refrec":{"BRefID":323241,"RR":"<b>Campos, P.-E.; Pichon, E.; Moriou, C.; Clerc, P.; Trépos, R.; Frederich, M.; De Voogd, N.; Hellio, C.; Gauvin-Bialecki, A.; Al-Mourabit, A.</b> (2019). New antimalarial and antimicrobial tryptamine derivatives from the marine sponge <i>Fascaplysinopsis reticulata</i>. <i>Mar. Drugs 17(3)</i>: 167. <a href=\"https://dx.doi.org/10.3390/md17030167\" target=\"_blank\">https://dx.doi.org/10.3390/md17030167</a>","BEntID":316713,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 17(3)</i>: 167. <a href=\"https://dx.doi.org/10.3390/md17030167\" target=\"_blank\">https://dx.doi.org/10.3390/md17030167</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Campos, P.-E.; Pichon, E.; Moriou, C.; Clerc, P.; Trépos, R.; Frederich, M.; De Voogd, N.; Hellio, C.; Gauvin-Bialecki, A.; Al-Mourabit, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Campos, P.-E. <i>et al.</i>","Englishabstract":"Chemical study of the CH<sub>2</sub>Cl<sub>2</sub>-MeOH (1:1) extract of the sponge <span class=\"html-italic\">Fascaplysinopsis reticulata</span> collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (<b>1</b>), 6-bromo-8,1′-dihydro-isoplysin A (<b>2</b>) and 5,6-dibromo-8,1′-dihydro-isoplysin A (<b>3</b>), along with the synthetically known 8-oxo-tryptamine (<b>4</b>) and the three known molecules from the same family, tryptamine (<b>5</b>), (<span class=\"html-italic\">E</span>)-6-bromo-2′-demethyl-3′-<span class=\"html-italic\">N</span>-methylaplysinopsin (<b>6</b>) and (<span class=\"html-italic\">Z</span>)-6-bromo-2′-demethyl-3′-<span class=\"html-italic\">N</span>-methylaplysinopsin (<b>7</b>). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (<b>2</b>) and (<b>3</b>), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards <span class=\"html-italic\">Vibrio natrigens</span>, and (<b>5</b>), with MIC values of 1 µg/mL towards <span class=\"html-italic\">Vibrio carchariae</span>. In addition the known 8-oxo-tryptamine (<b>4</b>) and the mixture of the (<span class=\"html-italic\">E</span>)-6-bromo-2′-demethyl-3′-<span class=\"html-italic\">N</span>-methylaplysinopsin (<b>6</b>) and (<span class=\"html-italic\">Z</span>)-6-bromo-2′-demethyl-3′-<span class=\"html-italic\">N</span>-methylaplysinopsin (<b>7</b>) showed moderate antiplasmodial activity against <span class=\"html-italic\">Plasmodium falciparum</span> with IC<sub>50</sub> values of 8.8 and 8.0 µg/mL, respectively.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"New antimalarial and antimicrobial tryptamine derivatives from the marine sponge <i>Fascaplysinopsis reticulata</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-18 01:32:16.521166","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Fascaplysinopsis reticulata; marine sponge; tryptamine alkaloids;antimalarial activity; antimicrobial activity","OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2020-04-16","DateCreate":"2020-04-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000466398200031","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md17030167"},"refs":null,"anarec":{"AnaID":323241,"PubliDate":2019,"Pagination":"167","XtraPublOfAnaID":null,"ISBN":null,"Volume":"17","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. 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