{"refrec":{"BRefID":323709,"RR":"<b>Vitale, G.A.; Sciarretta, M.; Palma Esposito, F.; January, G.G.; Giaccio, M.; Bunk, B.; Spröer, C.; Bajerski, F.; Power, D.; Festa, C.; Monti, M.C.; D’Auria, M.V.; de Pascale, D.</b> (2020). Genomics–metabolomics profiling disclosed marine <i>Vibrio spartinae</i> 3.6 as a producer of a new branched side chain prodigiosin. <i>J. Nat. Prod. 83(5)</i>: 1495-1504. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.9b01159\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.9b01159</a>","BEntID":317181,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Nat. Prod. 83(5)</i>: 1495-1504. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.9b01159\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.9b01159</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vitale, G.A.; Sciarretta, M.; Palma Esposito, F.; January, G.G.; Giaccio, M.; Bunk, B.; Spröer, C.; Bajerski, F.; Power, D.; Festa, C.; Monti, M.C.; D’Auria, M.V.; de Pascale, D.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vitale, G.A. <i>et al.</i>","Englishabstract":"A wide range of prescreening tests for antimicrobial activity of 59 bacterial isolates from sediments of Ria Formosa Lagoon (Algarve, Portugal) disclosed <i>Vibrio spartinae</i> 3.6 as themost active antibacterial producing strain. This bacterial strain,which has not previously been submitted for chemical profiling,was subjected to de novo whole genome sequencing, which aided inthe discovery and elucidation of a prodigiosin biosynthetic genecluster that was predicted by the bioinformatic tool KEGG BlastKoala. Comparative genomics led to the identification of anew membrane di-iron oxygenase-like enzyme, annotated asVspart_02107, which is likely to be involved in the biosynthesisof cycloprodigiosin and analogues. The combined genomics−metabolomics profiling of the strain led to the isolation andidentification of one new branched-chain prodigiosin (5) and to the detection of two new cyclic forms. Furthermore, the evaluationof the minimum inhibitory concentrations disclosed the major prodigiosin as very effective against multi-drug-resistant pathogens including <i>Stenotrophomonas maltophilia</i>, a clinical isolate of Listeria monocytogenes, as well as some human pathogens reported by the World Health Organization as prioritized targets.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Genomics–metabolomics profiling disclosed marine <i>Vibrio spartinae</i> 3.6 as a producer of a new branched side chain prodigiosin","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-16 01:33:16.015813","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2021-08-09","DateCreate":"2020-04-30","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000537539300017","VABBcode":null,"OpenAcc":0,"DOI":"10.1021/acs.jnatprod.9b01159"},"refs":null,"anarec":{"AnaID":323709,"PubliDate":2020,"Pagination":"1495-1504","XtraPublOfAnaID":null,"ISBN":null,"Volume":"83","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43089,"SerRR":"Journal of Natural Products. 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