{"refrec":{"BRefID":324118,"RR":"<b>Deghrigue, M.; Dellai, A.; Akremi, N.; Le Morvan, V.; Robert, J.; Bouraoui, A.</b> (2013). Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the Mediterranean gorgonian <i>Eunicella singularis</i>. <i>Environ. Toxicol. Pharmacol. 36(2)</i>: 339-346. <a href=\"https://dx.doi.org/10.1016/j.etap.2013.04.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.etap.2013.04.014</a>","BEntID":317593,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Environ. Toxicol. Pharmacol. 36(2)</i>: 339-346. <a href=\"https://dx.doi.org/10.1016/j.etap.2013.04.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.etap.2013.04.014</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Deghrigue, M.; Dellai, A.; Akremi, N.; Le Morvan, V.; Robert, J.; Bouraoui, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Deghrigue, M. <i>et al.</i>","Englishabstract":"The present study was conducted to evaluate the antiproliferative and antioxidant activities of organic extract and its polar fractions from <i>Eunicella singularis</i> (Esper 1794). Organic extract and two fractions of <i>E. singularis</i> (F2 and F3) were screened for the presence of phenolic compounds, terpenoids and glycosides. The antiproliferative activity of <i>E. singularis</i> organic extract and its polar fractions was evaluated on human cancer cell lines (A549, lung cell carcinoma; HCT15, colon cell carcinoma and MCF7, breast adenocarcinoma), using the MTT colorimetric method and clonogenic assay, as well as the antioxidant activity, using the stable radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and the FRAP assays. The fractions F2 and F3 showed significant total phenolic content (40 and 35.72 mg gallic-acid equivalent/g dried sample), respectively, and important antiproliferative properties against the cancer cell lines. The IC<sub>50</sub> values, ranged from 36 to 274 μg/ml for A549; 93 to 426 μg/ml for HCT15; and 52 to 225 μg/ml for MCF7 and in the clonogenic inhibition assay from 18 to 134 μg/ml for A549; 43 to 357 μg/ml for HCT15; and 17 to 160 μg/ml for MCF7. Using the DPPH method, the fraction F2 exhibited the strongest radical scavenging activity, with IC<sub>50</sub> 0.08 mg/ml, which approaches the activity of the powerful antioxidant standard, ascorbic acid (IC<sub>50</sub> = 0.064 mg/ml). The reducing power of the samples was in the following order: F2 > organic extract > F3. These results suggest that <i>E. singularis</i> fractions might be used as a potential source of natural antioxidant and antitumor agents. The purification and determination of the chemical structures of compounds in these active fractions are under investigation. The results could provide a compound(s) with a promising role in future medicines.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the Mediterranean gorgonian <i>Eunicella singularis</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-23 01:33:01.945530","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Antiproliferative activity; Antioxidant; Eunicella singularis","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2020-05-26","DateCreate":"2020-05-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000324082900012","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.etap.2013.04.014"},"refs":null,"anarec":{"AnaID":324118,"PubliDate":2013,"Pagination":"339-346","XtraPublOfAnaID":null,"ISBN":null,"Volume":"36","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":75266,"SerRR":"Environmental Toxicology and Pharmacology. 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