{"refrec":{"BRefID":324301,"RR":"<b>Korpayev, S.; Heydari, H.; Koc, A.; Gözcelioglu, B.; Konuklugil, B.</b> (2020). Additional screening of bioactivities in the Turkish gorgonian <i>Paramuricea clavata</i> (Risso, 1826) with isolation of secondary metabolites. <i>Cah. Biol. Mar. 61</i>: 25-32. <a href=\"https://dx.doi.org/10.21411/CBM.A.EB81DEF7\" target=\"_blank\">https://dx.doi.org/10.21411/CBM.A.EB81DEF7</a>","BEntID":317777,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Cah. Biol. Mar. 61</i>: 25-32. <a href=\"https://dx.doi.org/10.21411/CBM.A.EB81DEF7\" target=\"_blank\">https://dx.doi.org/10.21411/CBM.A.EB81DEF7</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Korpayev, S.; Heydari, H.; Koc, A.; Gözcelioglu, B.; Konuklugil, B.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Korpayev, S. <i>et al.</i>","Englishabstract":"During the course of our investigation for isolation of biological active compounds from marine organisms in the Turkish seas, we looked for secondary metabolites and bioactivities in the soft coral, <i>Paramuricea clavata</i> (Risso, 1826) collected from the coast of Ayvalık (Turkish coasts). As a result of this study, β-sitosterol and diheptyl phthalate have been isolated from <i>P.clavata</i> following their structural identification by NMR spectrometry and their subsequent comparison to the existent spectra dataset. The antioxidant potential of crude extracts of <i>P. clavata</i> was determined by the scavenging of superoxide, nitric oxide radicals and DPPH assays. In addition, the cytotoxic activity of crude extracts was tested against HCT-116 colon cancer cell lines by MTT assay. The P. clavata extract decreased HCT-116 and HEP-2 cancer cells viability significantly between 10-200 µg.mL<sup>-1</sup> dose range after 72 h incubation. The screening for free radical scavenging bioactivities by DPPH, SO and NO displayed IC50: 231.23 ± 0.4, 228.9 ± 0.32 and 243.8 ± 0.46 µg.mL<sup>-1</sup> respectively for the dried extract, confirming its noteworthy source of antioxidant compounds. While the extract exhibits the highest tyrosinase inhibitory activity (IC50: 73.73 ± 2.31 µg.mL<sup>-1</sup>), moderate antimicrobial activities against gram positive, gram negative and yeast strains, it did not seem to display acetylcholinesterase inhibitory activity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Additional screening of bioactivities in the Turkish gorgonian <i>Paramuricea clavata</i> (Risso, 1826) with isolation of secondary metabolites","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-20 01:32:38.609191","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"acetylcholinesterase inhibitory; antioxidant; antimicrobial; cytotoxicity; paramuricea clavata","OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2020-05-18","DateCreate":"2020-05-18","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000545764200003","VABBcode":null,"OpenAcc":0,"DOI":"10.21411/CBM.A.EB81DEF7"},"refs":null,"anarec":{"AnaID":324301,"PubliDate":2020,"Pagination":"25-32","XtraPublOfAnaID":null,"ISBN":null,"Volume":"61","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42348,"SerRR":"Cahiers de Biologie Marine. Station Biologique de Roscoff: Paris.  ISSN 0007-9723; e-ISSN 2262-3094","StandardTitleSer":"Cahiers de Biologie Marine","ISSN":"0007-9723","AbbrevSer":"Cah. Biol. 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