BibliographicReference 325264

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Type: Bibliographic resource
Type of document: Journal article
BibLvlCode: AS
Title: Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment
Abstract: At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g⁻¹, 9 ng.g⁻¹, and 18 ng.g⁻¹) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.
WebOfScience code: https://www.webofscience.com/wos/woscc/full-record/WOS:000548531100021
Bibliographic citation: Essid, N.; Allouche, M.; Lazzem, M.; Harrath, A.M.; Mansour, L.; Alwasel, S.; Mahmoudi, E.; Beyrem, H.; Boufahja, F. (2020). Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment. Mar. Pollut. Bull. 157: 111375. https://dx.doi.org/10.1016/j.marpolbul.2020.111375
Is peer reviewed: true
Access rights: open access
Is accessible for free: true

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