{"refrec":{"BRefID":329193,"RR":"<b>Bracegirdle, J.; Stevenson, L.J.; Page, M.J.; Owen, J.G.; Keyzers, R.A.</b> (2020). Targeted isolation of rubrolides from the New Zealand marine tunicate <i>Synoicum kuranui</i>. <i>Mar. Drugs 18(7)</i>: 337. <a href=\"https://dx.doi.org/10.3390/md18070337\" target=\"_blank\">https://dx.doi.org/10.3390/md18070337</a>","BEntID":322799,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 18(7)</i>: 337. <a href=\"https://dx.doi.org/10.3390/md18070337\" target=\"_blank\">https://dx.doi.org/10.3390/md18070337</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bracegirdle, J.; Stevenson, L.J.; Page, M.J.; Owen, J.G.; Keyzers, R.A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bracegirdle, J. <i>et al.</i>","Englishabstract":"Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the marine tunicate <i>Synoicum kuranui</i>, comprised of many previously reported rubrolides, for new chemical entities. Within the rubrolide cluster, two masses that did not correspond to previously reported congeners were detected, and, following MS-guided fractionation, led to the isolation of new methylated rubrolides T (3) and (Z/E)–U (4). 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