{"refrec":{"BRefID":329346,"RR":"<b>Stairs, C.W.; Sharamshi, J.E.; Tamarit, D.; Eme, L.; Jorgensen, S.L.; Spang, A.; Ettema, T.J.G.</b> (2020). Chlamydial contribution to anaerobic metabolism during eukaryotic evolution. <i>Science Advances 6(35)</i>: eabb7258. <a href=\"https://dx.doi.org/10.1126/sciadv.abb7258\" target=\"_blank\">https://dx.doi.org/10.1126/sciadv.abb7258</a>","BEntID":322952,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Science Advances 6(35)</i>: eabb7258. <a href=\"https://dx.doi.org/10.1126/sciadv.abb7258\" target=\"_blank\">https://dx.doi.org/10.1126/sciadv.abb7258</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Stairs, C.W.; Sharamshi, J.E.; Tamarit, D.; Eme, L.; Jorgensen, S.L.; Spang, A.; Ettema, T.J.G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Stairs, C.W. <i>et al.</i>","Englishabstract":"The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H<SUB>2</SUB> exchange. However, there are no strong indications that modern eukaryotic H<SUB>2</SUB> metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H<SUB>2</SUB> metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales—a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H<SUB>2</SUB> metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H<SUB>2</SUB>metabolism reveal that Anoxychlamydiales homologs are the closest relatives to eukaryotic sequences. We propose that an ancestor of the Anoxychlamydiales contributed these key genes during the evolution of eukaryotes, supporting a mosaic evolutionary origin of eukaryotic metabolism.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Chlamydial contribution to anaerobic metabolism during eukaryotic evolution","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2020-10-13","DateCreate":"2020-09-15","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000563099200016","VABBcode":null,"OpenAcc":1,"DOI":"10.1126/sciadv.abb7258"},"refs":null,"anarec":{"AnaID":329346,"PubliDate":2020,"Pagination":"eabb7258","XtraPublOfAnaID":null,"ISBN":null,"Volume":"6","Issue":"35","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":248966,"SerRR":"Science Advances. 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