{"refrec":{"BRefID":329583,"RR":"<b>Konrad, C.; Kiss, G.; Torocsik, B.; Adam-Vizi, V.; Chinopoulos, C.</b> (2012). Absence of Ca<sup>2+</sup>-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in <i>C. crangon</i> and <i>P. serratus</i>. <i>PLoS One 7(6)</i>: e39839. <a href=\"https://dx.doi.org/10.1371/journal.pone.0039839\" target=\"_blank\">https://dx.doi.org/10.1371/journal.pone.0039839</a>","BEntID":323190,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>PLoS One 7(6)</i>: e39839. <a href=\"https://dx.doi.org/10.1371/journal.pone.0039839\" target=\"_blank\">https://dx.doi.org/10.1371/journal.pone.0039839</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Konrad, C.; Kiss, G.; Torocsik, B.; Adam-Vizi, V.; Chinopoulos, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Konrad, C. <i>et al.</i>","Englishabstract":"Mitochondria from the embryos of brine shrimp (<em>Artemia franciscana</em>) do not undergo Ca<sup>2+</sup>-induced permeability transition in the presence of a profound Ca<sup>2+</sup> uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-insensitive mitochondrial adenine nucleotide exchange, prompting the conjecture that refractoriness to bongkrekate and absence of Ca<sup>2+</sup>-induced permeability transition are somehow related phenomena. Here we report that mitochondria isolated from two other crustaceans, brown shrimp (<em>Crangon crangon</em>) and common prawn (<em>Palaemon serratus</em>) exhibited bongkrekate-sensitive mitochondrial adenine nucleotide transport, but lacked a Ca<sup>2+</sup>-induced permeability transition. Ca<sup>2+</sup> uptake capacity was robust in the absence of adenine nucleotides in both crustaceans, unaffected by either bongkrekate or cyclosporin A. Transmission electron microscopy images of Ca<sup>2+</sup>-loaded mitochondria showed needle-like formations of electron-dense material strikingly similar to those observed in mitochondria from the hepatopancreas of blue crab (<em>Callinectes sapidus</em>) and the embryos of <em>Artemia franciscana</em>. Alignment analysis of the partial coding sequences of the adenine nucleotide translocase (ANT) expressed in <em>Crangon crangon</em> and <em>Palaemon serratus</em> versus the complete sequence expressed in <em>Artemia franciscana</em> reappraised the possibility of the 208-214 amino acid region for conferring sensitivity to bongkrekate. However, our findings suggest that the ability to undergo Ca<sup>2+</sup>-induced mitochondrial permeability transition and the sensitivity of adenine nucleotide translocase to bongkrekate are not necessarily related phenomena.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Absence of Ca<sup>2+</sup>-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in <i>C. crangon</i> and <i>P. serratus</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2012,"MonPub":null,"DateUpdate":"2020-09-28","DateCreate":"2020-09-28","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000305892100109","VABBcode":null,"OpenAcc":1,"DOI":"10.1371/journal.pone.0039839"},"refs":null,"anarec":{"AnaID":329583,"PubliDate":2012,"Pagination":"e39839","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"6","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":123954,"SerRR":"PLoS One. 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