{"refrec":{"BRefID":330948,"RR":"<b>Ciftci, H.I.; Can, M.; Ellakwa, D.E.; Suner, S.C.; Ibrahim, M.A.; Oral, A.; Sekeroglu, N.; Özalp, B.; Otsuka, M.; Fujita, M.; Alparslan, M.; Radwan, M.O.</b> (2020). Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity. <i>Investigational New Drugs 38(5)</i>: 1326-1333. <a href=\"https://dx.doi.org/10.1007/s10637-020-00911-8\" target=\"_blank\">https://dx.doi.org/10.1007/s10637-020-00911-8</a>","BEntID":324559,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Investigational New Drugs 38(5)</i>: 1326-1333. <a href=\"https://dx.doi.org/10.1007/s10637-020-00911-8\" target=\"_blank\">https://dx.doi.org/10.1007/s10637-020-00911-8</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Ciftci, H.I.; Can, M.; Ellakwa, D.E.; Suner, S.C.; Ibrahim, M.A.; Oral, A.; Sekeroglu, N.; Özalp, B.; Otsuka, M.; Fujita, M.; Alparslan, M.; Radwan, M.O.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Ciftci, H.I. <i>et al.</i>","Englishabstract":"Marine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven’t been yet extensively explored. In the present study, three marine organisms (<i>Dysidea avara</i>, <i>Microcosmus sabatieri</i> and <i>Echinaster sepositus</i>) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC<sub>50</sub> less than 10&nbsp;μg/mL. On the contrary, the other two extracts exhibited no cytotoxic activity on all cells at 100&nbsp;μg/mL concentration. The sponge extract was tested for its capacity to induce apoptosis in cancer cells and to inhibit a panel of tyrosine kinases showing remarkable results. The outcome of this study represents a platform for discovery of new chemotherapeutic agents of marine natural origin.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2020-11-16","DateCreate":"2020-11-16","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000516185300001","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s10637-020-00911-8"},"refs":null,"anarec":{"AnaID":330948,"PubliDate":2020,"Pagination":"1326-1333","XtraPublOfAnaID":null,"ISBN":null,"Volume":"38","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":270784,"SerRR":"Investigational New Drugs. Springer: Dordrecht.  ISSN 0167-6997; e-ISSN 1573-0646","StandardTitleSer":"Investigational New Drugs","ISSN":"0167-6997","AbbrevSer":null,"StandardTitleMon":null,"StartPage":1326,"Pages":8,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Ciftci","Firstname":"Halil","Initials":"H.I.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429755,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Can","Firstname":"Mustafa","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429756,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ellakwa","Firstname":"Doha","Initials":"D.E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429757,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Suner","Firstname":"Salih","Initials":"S.C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429758,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ibrahim","Firstname":"Mohamed","Initials":"M.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429759,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Oral","Firstname":"Ayhan","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429760,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sekeroglu","Firstname":"Nazim","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429761,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Özalp","Firstname":"Baris","Initials":"B.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429762,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Otsuka","Firstname":"Masami","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429763,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Fujita","Firstname":"Mikako","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429764,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Alparslan","Firstname":"Mustafa","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":6182,"OrderNr":11,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Radwan","Firstname":"Mohamed","Initials":"M.O.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":324559,"AutID":429766,"OrderNr":12,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":[{"DasID":6462,"Acronym":null,"Citation":"Linares, Cristina; Figuerola, Laura; Gómez-Gras, Daniel; Pagès-Escolà, Marta; Olvera, Àngela, Aubach, Àlex; Amate, Roger; Figuerola, Blanca; Kersting, Diego; Ledoux, Jean-Baptiste; López-Sanz, Àngel; López-Sendino, Paula; Medrano, Alba; Garrabou, Joaquim; (2020); CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019","StandardTitle":"CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019.","RelationID":2,"DOI":"10.14284/467"}],"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":355301,"LibID":36,"BRefID":330948,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"355301","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Springer","City":"Dordrecht"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"EMODNET","ShortName":"emodnet"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"552":{"SpName":"EMODNET","SpColID":552,"ParSpColID":null,"TopParID":null,"ShortName":"emodnet","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"emodnet"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":324559,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":324559,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1007/s10637-020-00911-8","externalID":"10.1007/s10637-020-00911-8","URLTypeCode":"DOI","URLID":87857,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2020-11-16 07:00:50.793000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-11-16 07:00:50.793000","timezone_type":3,"timezone":"Europe/Brussels"}}}