Document of bibliographic reference 331082

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Furanoterpene diversity and variability in the marine sponge Spongia officinalis, from untargeted LC–MS/MS metabolomic profiling to furanolactam derivatives

Abstract

The Mediterranean marine sponge Spongia officinalis has been reported as a rich source of secondary metabolites and also as a bioindicator of water quality given its capacity to concentrate trace metals. In this study, we evaluated the chemical diversity within 30 S. officinalis samples collected over three years at two sites differentially impacted by anthropogenic pollutants located near Marseille (South of France). Untargeted liquid chromatography—mass spectrometry (LC–MS) metabolomic profiling (C18 LC, ESI-Q-TOF MS) combined with XCMS Online data processing and multivariate statistical analysis revealed 297 peaks assigned to at least 86 compounds. The spatio-temporal metabolite variability was mainly attributed to variations in relative content of furanoterpene derivatives. This family was further characterized through LC–MS/MS analyses in positive and negative ion modes combined with molecular networking, together with a comprehensive NMR study of isolated representatives such as demethylfurospongin-4 and furospongin-1. The MS/MS and NMR spectroscopic data led to the identification of a new furanosesterterpene, furofficin (2), as well as two derivatives with a glycinyl lactam moiety, spongialactam A (12a) and B (12b). This study illustrates the potential of untargeted LC–MS metabolomics and molecular networking to discover new natural compounds even in an extensively studied organism such as S. officinalis. It also highlights the effect of anthropogenic pollution on the chemical profiles within the sponge.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000407339000016

Bibliographic citation

Bauvais, C.; Bonneau, N.; Blond, A.; Pérez, T.; Bourguet-Kondracki, M.-L.; Zirah, S. (2017). Furanoterpene diversity and variability in the marine sponge Spongia officinalis, from untargeted LC–MS/MS metabolomic profiling to furanolactam derivatives. Metabolites 7(2): 27. https://dx.doi.org/10.3390/metabo7020027

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true