{"refrec":{"BRefID":331238,"RR":"<b>Zhang, Fan; Zhao, Miao; Braun, Doug R.; Ericksen, Spencer S.; Piotrowski, Jeff S.; Nelson, Justin; Peng, Jian; Ananiev, Gene E.; Chanana, Shaurya; Barns, Kenneth; Fossen, Jen; Sanchez, Hiram; Chevrette, Marc G.; Guzei, Ilia A.; Zhao, Changgui; Guo, Le; Tang, Weiping; Currie, Cameron R.; Rajski, Scott R.; Audhya, Anjon; Andes, David R.; Bugni, Tim S.</b> (2020). A marine microbiome antifungal targets urgent-threat drug-resistant fungi. <i>Science (Wash.) 370(6519)</i>: 974-978. <a href=\"https://dx.doi.org/10.1126/science.abd6919\" target=\"_blank\">https://dx.doi.org/10.1126/science.abd6919</a>","BEntID":324849,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Science (Wash.) 370(6519)</i>: 974-978. <a href=\"https://dx.doi.org/10.1126/science.abd6919\" target=\"_blank\">https://dx.doi.org/10.1126/science.abd6919</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zhang, Fan; Zhao, Miao; Braun, Doug R.; Ericksen, Spencer S.; Piotrowski, Jeff S.; Nelson, Justin; Peng, Jian; Ananiev, Gene E.; Chanana, Shaurya; Barns, Kenneth; Fossen, Jen; Sanchez, Hiram; Chevrette, Marc G.; Guzei, Ilia A.; Zhao, Changgui; Guo, Le; Tang, Weiping; Currie, Cameron R.; Rajski, Scott R.; Audhya, Anjon; Andes, David R.; Bugni, Tim S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zhang, Fan <i>et al.</i>","Englishabstract":"New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant <i>Candida auris</i>. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as <i>C. auris</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A marine microbiome antifungal targets urgent-threat drug-resistant fungi","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-13 01:31:45.777642","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2020-11-20","DateCreate":"2020-11-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000594441500050","VABBcode":null,"OpenAcc":0,"DOI":"10.1126/science.abd6919"},"refs":null,"anarec":{"AnaID":331238,"PubliDate":2020,"Pagination":"974-978","XtraPublOfAnaID":null,"ISBN":null,"Volume":"370","Issue":"6519","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43776,"SerRR":"Science (Washington). American Association for the Advancement of Science: New York, N.Y.  ISSN 0036-8075; e-ISSN 1095-9203","StandardTitleSer":"Science (Washington)","ISSN":"0036-8075","AbbrevSer":"Science (Wash.)","StandardTitleMon":null,"StartPage":974,"Pages":5,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":331236,"RefStrFull":"<b>Cowen, L.E.</b> (2020). Drugs from bugs in creatures of the sea. <i>Science (Wash.) 370(6519)</i>: 906-907. <a href=\"https://dx.doi.org/10.1126/science.abf1675\" target=\"_blank\">https://dx.doi.org/10.1126/science.abf1675</a>","RelID":4,"Relation":"Related to","StandardTitle":"Drugs from bugs in creatures of the sea"}],"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":null,"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":355589,"LibID":36,"BRefID":331238,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"355589","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"American Association for the Advancement of Science","City":"New York, N.Y"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":324849,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":324849,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1126/science.abd6919","externalID":"10.1126/science.abd6919","URLTypeCode":"DOI","URLID":88185,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2020-11-20 11:29:41.683000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Chisala, Chilekwa, C.","updSesDate":{"date":"2020-11-20 11:29:41.683000","timezone_type":3,"timezone":"Europe/Brussels"}}}