{"refrec":{"BRefID":331946,"RR":"<b>Zabelskii, D.; Alekseev, A.; Kovalev, K.; Rankovic, V.; Balandin, T.; Soloviov, D.; Bratanov, D.; Savelyeva, E.; Podolyak, E.; Volkov, D.; Vaganova, S.; Astashkin, R.; Chizhov, I.; Yutin, N.; Rulev, M.; Popov, A.; Eria-Oliveira, A.S.; Rokitskaya, T.; Mager, T.; Antonenko, Y.; Rosselli, R.; Armeev, G.; Shaitan, K.; Vivaudou, M.; Büldt, G.; Rogachev, A.; Rodriguez-Valera, F.; Kirpichnikov, M.; Moser, T.; Offenhäusser, A.; Willbold, D.; Koonin, E.; Bamberg, E.; Gordeliy, V.</b> (2020). Viral rhodopsins 1 are an unique family of light-gated cation channels. <i>Nature Comm. 11(1)</i>: 5705. <a href=\"https://doi.org/10.1038/s41467-020-19457-7\" target=\"_blank\">https://doi.org/10.1038/s41467-020-19457-7</a>","BEntID":325558,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 11(1)</i>: 5705. <a href=\"https://doi.org/10.1038/s41467-020-19457-7\" target=\"_blank\">https://doi.org/10.1038/s41467-020-19457-7</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zabelskii, D.; Alekseev, A.; Kovalev, K.; Rankovic, V.; Balandin, T.; Soloviov, D.; Bratanov, D.; Savelyeva, E.; Podolyak, E.; Volkov, D.; Vaganova, S.; Astashkin, R.; Chizhov, I.; Yutin, N.; Rulev, M.; Popov, A.; Eria-Oliveira, A.S.; Rokitskaya, T.; Mager, T.; Antonenko, Y.; Rosselli, R.; Armeev, G.; Shaitan, K.; Vivaudou, M.; Büldt, G.; Rogachev, A.; Rodriguez-Valera, F.; Kirpichnikov, M.; Moser, T.; Offenhäusser, A.; Willbold, D.; Koonin, E.; Bamberg, E.; Gordeliy, V.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zabelskii, D. <i>et al.</i>","Englishabstract":"Phytoplankton is the base of the marine food chain as well as oxygen and    carbon cycles and thus plays a global role in climate and ecology.    Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and    regulate the phytoplankton dynamics encompass genes of rhodopsins of two    distinct families. Here, we present a functional and structural    characterization of two proteins of viral rhodopsin group 1, OLPVR1 and    VirChR1. Functional analysis of VirChR1 shows that it is a highly    selective, Na<sup>+</sup>/K<sup>+</sup>-conducting channel and, in contrast    to known cation channelrhodopsins, it is impermeable to Ca<sup>2+</sup>    ions. We show that, upon illumination, VirChR1 is able to drive neural    firing. The 1.4 Å resolution structure of OLPVR1 reveals remarkable    differences from the known channelrhodopsins and a unique ion-conducting    pathway. Thus, viral rhodopsins 1 represent a unique, large group of    light-gated channels (viral channelrhodopsins, VirChR1s). In nature,    VirChR1s likely mediate phototaxis of algae enhancing the host anabolic    processes to support virus reproduction, and therefore, might play a major    role in global phytoplankton dynamics. Moreover, VirChR1s have unique    potential for optogenetics as they lack possibly noxious Ca<sup>2+</sup>    permeability.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Viral rhodopsins 1 are an unique family of light-gated cation channels","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-10 01:32:33.353423","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"ion transport; virus-host interactions","OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2020-12-14","DateCreate":"2020-12-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000593975100009","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-020-19457-7"},"refs":null,"anarec":{"AnaID":331946,"PubliDate":2020,"Pagination":"5705","XtraPublOfAnaID":null,"ISBN":null,"Volume":"11","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. Nature Publishing Group: London.  ISSN 2041-1723; e-ISSN 2041-1723","StandardTitleSer":"Nature Communications","ISSN":"2041-1723","AbbrevSer":"Nature Comm.","StandardTitleMon":null,"StartPage":5705,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Rosselli","Firstname":"Riccardo","Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":325558,"AutID":400290,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MMB","InsFSN":"Koninklijk Nederlands Instituut voor Onderzoek der Zee; Marine Microbiology and Biogeochemistry","ORCID":null,"PersID":38313,"InsID":13655}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":325558,"BEntPrivate":null,"availability":[{"BInstID":356397,"LibID":2779,"BRefID":331946,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"356397","RFID":null,"PaidValue":null,"Medium":"Server","Description":null,"Acronym":null,"Library":"NIOZ","DutchTerm":null,"URL":null,"ClassifID":260,"Classification":"NIOZ Open Repository","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":null,"LoggedInReq":null,"Disclaimer":"Disclaimer_NIOZ","DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":397,"FileFormID":6,"LendableFlag":null,"PublicFlag":1,"orderLib":"NIOZ","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":805,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"805":{"SpName":"Koninklijk Nederlands Instituut voor Onderzoek der Zee","SpColID":805,"ParSpColID":null,"TopParID":null,"ShortName":"NIOZ","URLLocation":"https://www.vliz.be/imis/nioz/imis.php?refid=","LibID":2779,"OpenRepoFlag":1,"SpTypID":1,"TopParIDNotWebsite":null,"SpColPath":"NIOZ"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":325558,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":325558,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://doi.org/10.1038/s41467-020-19457-7","externalID":"10.1038/s41467-020-19457-7","URLTypeCode":"DOI","URLID":88643,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"daan.van.loon@nioz.nl","newSesDate":{"date":"2020-12-14 11:50:40.647000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"daan.van.loon@nioz.nl","updSesDate":{"date":"2020-12-14 11:50:40.647000","timezone_type":3,"timezone":"Europe/Brussels"}}}