{"refrec":{"BRefID":332435,"RR":"<b>Tian, Zhenyu; Zhao, Haoqi; Peter, Katherine T.; Gonzalez, Melissa; Wetzel, Jill; Wu, Christopher; Hu, Ximin; Prat, Jasmine; Mudrock, Emma; Hettinger, Rachel; Cortina, Allan E.; Biswas, Rajshree Ghosh; Kock, Flávio Vinicius Crizóstomo; Soong, Ronald; Jenne, Amy; Du, Bowen; Hou, Fan; He, Huan; Lundeen, Rachel; Gilbreath, Alicia; Sutton, Rebecca; Scholz, Nathaniel L.; Davis, Jay W.; Dodd, Michael C.; Simpson, Andre; McIntyre, Jenifer K.; Kolodziej, Edward P.</b> (2020). A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon. <i>Science (Wash.) 371(6525)</i>: 185-189. <a href=\"https://dx.doi.org/10.1126/science.abd6951\" target=\"_blank\">https://dx.doi.org/10.1126/science.abd6951</a>","BEntID":326047,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Science (Wash.) 371(6525)</i>: 185-189. <a href=\"https://dx.doi.org/10.1126/science.abd6951\" target=\"_blank\">https://dx.doi.org/10.1126/science.abd6951</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tian, Zhenyu; Zhao, Haoqi; Peter, Katherine T.; Gonzalez, Melissa; Wetzel, Jill; Wu, Christopher; Hu, Ximin; Prat, Jasmine; Mudrock, Emma; Hettinger, Rachel; Cortina, Allan E.; Biswas, Rajshree Ghosh; Kock, Flávio Vinicius Crizóstomo; Soong, Ronald; Jenne, Amy; Du, Bowen; Hou, Fan; He, Huan; Lundeen, Rachel; Gilbreath, Alicia; Sutton, Rebecca; Scholz, Nathaniel L.; Davis, Jay W.; Dodd, Michael C.; Simpson, Andre; McIntyre, Jenifer K.; Kolodziej, Edward P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tian, Zhenyu <i>et al.</i>","Englishabstract":"In U.S. Pacific Northwest coho salmon (<i>Oncorhynchus kisutch</i>), stormwater exposure annually causes unexplained acute mortality when adult salmon migrate to urban creeks to reproduce. By investigating this phenomenon, we identified a highly toxic quinone transformation product of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a globally ubiquitous tire rubber antioxidant. Retrospective analysis of representative roadway runoff and stormwater-affected creeks of the U.S. West Coast indicated widespread occurrence of 6PPD-quinone (<0.3 to 19 micrograms per liter) at toxic concentrations (median lethal concentration of 0.8 ± 0.16 micrograms per liter). These results reveal unanticipated risks of 6PPD antioxidants to an aquatic species and imply toxicological relevance for dissipated tire rubber residues.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-03 01:31:51.678973","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2021-01-08","DateCreate":"2021-01-08","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000606520400038","VABBcode":null,"OpenAcc":0,"DOI":"10.1126/science.abd6951"},"refs":null,"anarec":{"AnaID":332435,"PubliDate":2020,"Pagination":"185-189","XtraPublOfAnaID":null,"ISBN":null,"Volume":"371","Issue":"6525","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43776,"SerRR":"Science (Washington). American Association for the Advancement of Science: New York, N.Y.  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