{"refrec":{"BRefID":33280,"RR":"Pane, E.F.; Richards, J.G.; Wood, C.M. (2003). Acute waterborne nickel toxicity in the rainbow trout (Oncorhynchus mykiss) occurs by a respiratory rather than ionoregulatory mechanism. Aquat. Toxicol. 63(1): 65-82. https://dx.doi.org/10.1016/S0166-445X(02)00131-5","BEntID":33280,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". Aquat. Toxicol. 63(1): 65-82. https://dx.doi.org/10.1016/S0166-445X(02)00131-5","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Pane, E.F.; Richards, J.G.; Wood, C.M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Pane, E.F.; Richards, J.G.; Wood, C.M.","Englishabstract":"The acute mechanism of toxicity of waterborne nickel (Ni) was investigated in the rainbow trout (Oncorhynch mykiss) Lake Ontario water, where the 96-h LC50 for juvenile trout (1.5-3.5 g) was 15.3 mg (12.7-19.0, 95% C.L.) dissolved Ni l-1. No marked impact of Ni exposure on average unidirectional or net fluxes of Na+, Cl-, or Ca2+ was observed in juvenile trout exposed for 48-60 h to 15.6 mg Ni l-1 as NiSO4. Furthermore, when adult rainbow trout (200-340 g) were fitted with indwelling dorsal aortic catheters and exposed for 117 h to 11.6 mg Ni l-1 as NiSO4, plasma ions (Na+, Cl-, Ca2+, and Mg2+) were all well conserved. However, mean arterial oxygen tension dropped gradually to ~35% of control values. This drop in PaO2 was accompanied by an acidosis primarily of respiratory origin. PaCO2 rose to more than double control values with a concomitant drop in arterial pH of 0.15 units. Acute respiratory toxicity was further evidenced by a significant increase in hematocrit (Ht), and plasma lactate, and a significant decrease in spleen hemoglobin (Hb). Following 117 h of exposure to 11.6 mg Ni l-1, the gill, intestine, plasma, kidney, stomach, and heart accumulated Ni significantly, with increases of 60, 34, 28, 11, 8, and 3-fold, respectively. Brain, white muscle, liver, and bile did not significantly accumulate Ni. Plasma Ni exhibited a remarkable linear increase with time to levels approximately 30-fold higher than controls. We conclude that in contrast to most other metals, Ni is primarily a respiratory, rather than an ionoregulatory, toxicant at exposure levels close to the 96-h LC50. The implications of a waterborne metal as an acute respiratory toxicant (as opposed to ionoregulatory toxicants such as Cu, Ag, Cd, or Zn) with respect to toxicity modeling are discussed.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Acute waterborne nickel toxicity in the rainbow trout (Oncorhynchus mykiss) occurs by a respiratory rather than ionoregulatory mechanism","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-14 01:31:05.577823","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":"Rainbow trout; Waterborne; Respiratory toxicity; Ionoregulation","Notes":null,"AnaPub":2003,"MonPub":null,"DateUpdate":"2019-08-05","DateCreate":"2003-03-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000181493000005","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/S0166-445X(02)00131-5"},"refs":null,"anarec":{"AnaID":33280,"PubliDate":2003,"Pagination":"65-82","XtraPublOfAnaID":null,"ISBN":null,"Volume":"63","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514","StandardTitleSer":"Aquatic Toxicology","ISSN":"0166-445X","AbbrevSer":"Aquat. Toxicol.","StandardTitleMon":null,"StartPage":65,"Pages":18,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":{"Line1":"1280 Main Street West, Hamilton","Email":"panee@mcmaster.ca","Line2":null,"EnvName":"Canada"},"othpubs":null,"ownerships":null,"authors":[{"AutName":"Pane","Firstname":null,"Initials":"E.F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":33280,"AutID":35858,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":1,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Richards","Firstname":null,"Initials":"J.G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":33280,"AutID":35859,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Wood","Firstname":"Chris","Initials":"C.M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":33280,"AutID":2525,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":334610,"LibID":36,"BRefID":33280,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"334610","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"
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