{"refrec":{"BRefID":337384,"RR":"<b>Rodriguez Jimenez, A.; Dechamps, E.; Giaux, A.; Goetghebuer, L.; Bauwens, M.; Willenz, P.; Flahaut, S.; Laport, M.S.; George, I.F.</b> (2021). The sponges <i>Hymeniacidon perlevis</i> and <i>Halichondria panicea</i> are reservoirs of antibiotic-producing bacteria against multi-drug resistant <i>Staphylococcus aureus</i>. <i>J. Appl. Microbiol. 131(2)</i>: 706-718. <a href=\"https://hdl.handle.net/10.1111/jam.14999\" target=\"_blank\">https://hdl.handle.net/10.1111/jam.14999</a>","BEntID":334006,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Appl. Microbiol. 131(2)</i>: 706-718. <a href=\"https://hdl.handle.net/10.1111/jam.14999\" target=\"_blank\">https://hdl.handle.net/10.1111/jam.14999</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Rodriguez Jimenez, A.; Dechamps, E.; Giaux, A.; Goetghebuer, L.; Bauwens, M.; Willenz, P.; Flahaut, S.; Laport, M.S.; George, I.F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Rodriguez Jimenez, A. <i>et al.</i>","Englishabstract":"Aims</h3>                        <p>Evaluation of the antibacterial activity of cultivable bacteria associated with the marine sponges <i>Hymeniacidon perlevis</i> and <i>Halichondria panicea</i> against multi-drug–resistant <i>Staphylococcus aureus</i>.            </p>                     </section>                  <section class=\"article-section__content\" id=\"jam14999-sec-0002\">                        <h3 class=\"article-section__sub-title section1\" id=\"jam14999-sec-0002-title\"> Methods and Results</h3>                        <p>One hundred and fourteen bacterial isolates were recovered from <i>H. perlevis</i> and <i>H. panicea</i>. Antibacterial action was demonstrated by 70% of the isolates against reference strain <i>Staphylococcus aureus</i> ATCC 29213 and by 31·6% against <i>Pseudomonas aeruginosa</i> ATCC 27853 in agar overlay assays. Antibacterial potential was further analysed against 36 multi-drug–resistant hospital <i>Staphylococcus aureus</i> strains with diverse resistance profiles. Among the 80 isolates positive against <i>S. aureus</i> ATCC 29213, 76·3% were active against at least one clinical <i>S. aureus</i> pathogen and 73·6% inhibited one or more methicillin-resistant (MRSA) and vancomycin non-susceptible <i>S. aureus</i> strains. In addition, 41·3% inhibited all vancomycin nonsusceptible MRSA strains.            </p>                     </section>                  <section class=\"article-section__content\" id=\"jam14999-sec-0003\">                        <h3 class=\"article-section__sub-title section1\" id=\"jam14999-sec-0003-title\"> Conclusions</h3>                        <p>Culturable bacteria associated to <i>H. perlevis</i> and <i>H. panicea</i> are promising sources of antibacterial compounds of great pharmaceutical interest.            </p>                     </section>                  <section class=\"article-section__content\" id=\"jam14999-sec-0004\">                        <h3 class=\"article-section__sub-title section1\" id=\"jam14999-sec-0004-title\"> Significance and Impact of the Study</h3>                        <p>This study was the first to explore the antibacterial potential of culturable bacteria associated with the marine sponges <i>H. perlevis</i> and <i>H. panicea</i> against MDR bacteria. This is the first report of antibacterial activity by <i>Aquimarina</i>, <i>Denitrobaculum, Maribacter</i> and <i>Vagococcus</i> isolates against MDR <i>S. aureus</i> strains, including vancomycin nonsusceptible and methicillin-resistant ones, against which new antibiotics are urgently needed.            </p>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The sponges <i>Hymeniacidon perlevis</i> and <i>Halichondria panicea</i> are reservoirs of antibiotic-producing bacteria against multi-drug resistant <i>Staphylococcus aureus</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-02 01:33:16.482863","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"antibiotics; antimicrobials; environmental; resistance; staphylococci","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-07-26","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000612822600001","VABBcode":null,"OpenAcc":0,"Handle":"10.1111/jam.14999"},"refs":null,"anarec":{"AnaID":337384,"PubliDate":2021,"Pagination":"706-718","XtraPublOfAnaID":null,"ISBN":null,"Volume":"131","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45067,"SerRR":"Journal of Applied Microbiology. 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