{"refrec":{"BRefID":337456,"RR":"<b>Goikoetxea, A.; Sadoul, B.; Blondeau-Bidet, E.; Aerts, J.; Blanc, M.-O.; Parrinello, H.; Barrachina, C.; Pratlong, M.; Geffroy, B.</b> (2021). Genetic pathways underpinning hormonal stress responses in fish exposed to short- and long-term warm ocean temperatures. <i>Ecol. Indic. 120</i>: 106937. <a href=\"https://hdl.handle.net/10.1016/j.ecolind.2020.106937\" target=\"_blank\">https://hdl.handle.net/10.1016/j.ecolind.2020.106937</a>","BEntID":334079,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Ecol. Indic. 120</i>: 106937. <a href=\"https://hdl.handle.net/10.1016/j.ecolind.2020.106937\" target=\"_blank\">https://hdl.handle.net/10.1016/j.ecolind.2020.106937</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Goikoetxea, A.; Sadoul, B.; Blondeau-Bidet, E.; Aerts, J.; Blanc, M.-O.; Parrinello, H.; Barrachina, C.; Pratlong, M.; Geffroy, B.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Goikoetxea, A. <i>et al.</i>","Englishabstract":"Changes in ocean water temperature associated with global climate change are bound to enormously affect fish populations, with potential major economic consequences in the aquaculture and fisheries industries. A link between temperature fluctuations and changes in fish stress response is well established. In this study, we aimed to assess the effects of a short- (4&nbsp;days) or a long-term (4&nbsp;months) exposure to warm temperature in the stress physiology of European sea bass (<em>Dicentrarchus labrax</em>) larvae and juveniles. First, cortisol (<em>i.e.</em> the main stress hormone in fishes) analysis was used to confirm that a steady and short-term elevation of temperature acts as a physiological stressful event in these fish, and cortisol release is indeed above a metabolic increase linked to temperature. Moreover, our results verified that measurement of cortisol released into the water can be reliably employed as a non-invasive indicator of acute thermal stress in experimental conditions. Secondly, the different effects on the genetic cascade underlying the stress response between long-term low or high thermal treatments were evaluated at two larval development stages via candidate-gene and whole-transcriptome approaches. Interestingly, opposite expression for some key stress genes (<em>nr3c1, nr3c2</em> and <em>hsd11b2</em>) were observed between developmental stages, highlighting the distinct adaptive mechanisms controlling the primary and secondary responses to a stressor. Surprising expression patterns for some understudied genes involved in the stress axis were also revealed, including <em>crhr1, mc2r, mc5r, trh or trhr,</em> which should be further explored. Finally, evaluation of cortisol content in scales was successfully used as a biomarker of chronic thermal stress, with 10x more cortisol in fish kept at 21&nbsp;°C vs 16&nbsp;°C after 4&nbsp;months, supporting the gene expression results observed. The use of such a method as a proxy of long-term stress, unprecedented in the literature, holds a vast array of applications in further research, in particular, in the investigation of the impact of global warming on wild fish populations.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Genetic pathways underpinning hormonal stress responses in fish exposed to short- and long-term warm ocean temperatures","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-21 01:33:00.254533","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Cortisol; Glucocorticoid receptors; Transcriptomics; Scales; Commercial fish","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-05-20","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000591880800008","VABBcode":null,"OpenAcc":1,"Handle":"10.1016/j.ecolind.2020.106937"},"refs":null,"anarec":{"AnaID":337456,"PubliDate":2021,"Pagination":"106937","XtraPublOfAnaID":null,"ISBN":null,"Volume":"120","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45477,"SerRR":"Ecological Indicators. 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