{"refrec":{"BRefID":337573,"RR":"<b>Kalina, R.S.; Peigneur, S.; Gladkikh, I.N.; Dmitrenok, P.S.; Kim, N.Y.; Leychenko, E.V.; Monastyrnaya, M.M.; Tytgat, J.; Kozlovskaya, E.P.</b> (2020). New sea anemone toxin RTX-VI selectively modulates voltage-gated sodium channels. <i>Doklady Biochemistry and Biophysics 495(1)</i>: 292-295. <a href=\"https://hdl.handle.net/10.1134/S1607672920060071\" target=\"_blank\">https://hdl.handle.net/10.1134/S1607672920060071</a>","BEntID":334196,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Doklady Biochemistry and Biophysics 495(1)</i>: 292-295. <a href=\"https://hdl.handle.net/10.1134/S1607672920060071\" target=\"_blank\">https://hdl.handle.net/10.1134/S1607672920060071</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kalina, R.S.; Peigneur, S.; Gladkikh, I.N.; Dmitrenok, P.S.; Kim, N.Y.; Leychenko, E.V.; Monastyrnaya, M.M.; Tytgat, J.; Kozlovskaya, E.P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kalina, R.S. <i>et al.</i>","Englishabstract":"A new neurotoxin RTX-VI that modulates the voltage-gated sodium channels (Na<sub>V</sub>) was isolated from the ethanolic extract of the sea anemone <i>Heteractis crispa</i>. Its amino acid sequence was determined using the combination of Edman degradation and tandem mass spectrometry. RTX-VI turned out to be an unusual natural analogue of the previously described sea anemone toxin RTX-III. The RTX-VI molecule consists of two disulfide-linked peptide chains and is devoid of Arg13, which is important for the selectivity and affinity of such peptides for the Na<sub>V</sub> channels. Electrophysiological screening of RTV-VI on Na<sub>V</sub> channel subtypes showed its selective interaction with the central nervous system (Na<sub>V</sub>1.2, Na<sub>V</sub>1.6) and insect (BgNa<sub>V</sub>1, VdNa<sub>V</sub>1) sodium channels.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"New sea anemone toxin RTX-VI selectively modulates voltage-gated sodium channels","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"sea anemone; Heteractis crispa; voltage-gated sodium channels; toxins; electrophysiology","OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2021-05-30","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000602077200005","VABBcode":null,"OpenAcc":0,"Handle":"10.1134/S1607672920060071"},"refs":null,"anarec":{"AnaID":337573,"PubliDate":2020,"Pagination":"292-295","XtraPublOfAnaID":null,"ISBN":null,"Volume":"495","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":267039,"SerRR":"Doklady Biochemistry and Biophysics. 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