{"refrec":{"BRefID":337739,"RR":"<b>Zou, P.; Yang, Q.; Wang, H.; Xie, G.; Cao, Z.; Chen, X.; Gao, W.; Huang, J.</b> (2020). <i>In vitro</i> disinfection efficacy and clinical protective effects of common disinfectants against acute hepatopancreatic necrosis disease (AHPND)-causing <i>Vibrio</i> isolates in Pacific white shrimp <i>Penaeus vannamei</i>. <i>J. Microbiol. 58(8)</i>: 675-686. <a href=\"https://hdl.handle.net/10.1007/s12275-020-9537-1\" target=\"_blank\">https://hdl.handle.net/10.1007/s12275-020-9537-1</a>","BEntID":334363,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Microbiol. 58(8)</i>: 675-686. <a href=\"https://hdl.handle.net/10.1007/s12275-020-9537-1\" target=\"_blank\">https://hdl.handle.net/10.1007/s12275-020-9537-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zou, P.; Yang, Q.; Wang, H.; Xie, G.; Cao, Z.; Chen, X.; Gao, W.; Huang, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zou, P. <i>et al.</i>","Englishabstract":"Acute hepatopancreatic necrosis disease (AHPND) is one of the most significant bacterial diseases in global shrimp culture, causing severe economic losses. In the present study, we carried out <i>in vitro</i> antimicrobial tests to investigate the disinfection efficacy of 14 common disinfectants toward different AHPND-causing <i>Vibrio</i> spp., including eight isolates of <i>V. parahaemolyticus</i>, four isolates of <i>V. campbellii</i>, and one isolate of <i>V. owensii</i>. Polyhexamethylene biguanidine hydrochloride (PHMB) was revealed to possess the strongest inhibitory activity. Through analyzing and evaluating the results of antimicrobial tests and acute toxicity test, we selected PHMB and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) for further clinical protection test. Clinical manifestations indicated that both PHMB (2 mg/L and 4 mg/L) and H<sub>2</sub>O<sub>2</sub> (12 mg/L) could effectively protect juvenile <i>Penaeus vannamei</i> from the infection of <i>V. parahaemolyticus</i> isolate <i>Vp</i>362 at 10<sup>6</sup> CFU/ml, and the survival rate was over 80%. When the bacterial concentration was reduced to 10<sup>5</sup> CFU/ml, 10<sup>4</sup> CFU/ml, and 10<sup>3</sup> CFU/ml, the survival rate after treated by 1 mg/L PHMB was 64.44%, 93.33%, and 100%, respectively. According to the results, PHMB and H<sub>2</sub>O<sub>2</sub> showed a lower toxicity while a better protection activity, particularly against a lower concentration of the pathogens. Therefore, these two disinfectants are proved to be promising disinfectants that can be applied to prevent and control AHPND in shrimp culture. Moreover, the methods of this study also provided valuable information for the prevention of other important bacterial diseases and suggested a reliable means for screening potential drugs in aquaculture.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"<i>In vitro</i> disinfection efficacy and clinical protective effects of common disinfectants against acute hepatopancreatic necrosis disease (AHPND)-causing <i>Vibrio</i> isolates in Pacific white shrimp <i>Penaeus vannamei</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-24 01:33:04.551601","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"AHPND; disinfectants; disinfection efficacy; toxicity; protection activity","OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2021-05-31","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000552686600005","VABBcode":null,"OpenAcc":0,"Handle":"10.1007/s12275-020-9537-1"},"refs":null,"anarec":{"AnaID":337739,"PubliDate":2020,"Pagination":"675-686","XtraPublOfAnaID":null,"ISBN":null,"Volume":"58","Issue":"8","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":227984,"SerRR":"Journal of Microbiology. 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