{"refrec":{"BRefID":337968,"RR":"<b>Deris, Z.M.; Iehata, S.; Ikhwanuddin, M.; Sahimi, M.B.M.K.; Do, T.D.; Sorgeloos, P.; Sung, Y.Y.; Wong, L.L.</b> (2020). Immune and bacterial toxin genes expression in different giant tiger prawn, <i>Penaeus monodon</i> post-larvae stages following AHPND-causing strain of <i>Vibrio parahaemolyticus</i> challenge. <i>Aquaculture Reports 16</i>: 100248. <a href=\"https://hdl.handle.net/10.1016/j.aqrep.2019.100248\" target=\"_blank\">https://hdl.handle.net/10.1016/j.aqrep.2019.100248</a>","BEntID":334592,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquaculture Reports 16</i>: 100248. <a href=\"https://hdl.handle.net/10.1016/j.aqrep.2019.100248\" target=\"_blank\">https://hdl.handle.net/10.1016/j.aqrep.2019.100248</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Deris, Z.M.; Iehata, S.; Ikhwanuddin, M.; Sahimi, M.B.M.K.; Do, T.D.; Sorgeloos, P.; Sung, Y.Y.; Wong, L.L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Deris, Z.M. <i>et al.</i>","Englishabstract":"Acute Hepatopancreatic Necrosis Disease (AHPND), a disease caused by <em>Vibrio parahaemolyticus</em> (Vp<sub>AHPND</sub>), kills Penaeid shrimps worldwide, resulting in severe economic losses during aquaculture. To further understand how <em>Penaeus monodon</em> post-larvae (PL) respond towards infection of this pathogenic bacterium, the expression of several important immune and bacterial toxin genes in three stages of <em>P. monodon</em> PL (PL15, PL30 and PL45) upon Vp<sub>AHPND</sub> challenge, were determined. A 20-hrs challenge test with 2.7 × 10<sup>7</sup> cfu ml<sup>−1</sup> of Vp<sub>AHPND</sub> resulted 81, 65 and 1.7% mortality respectively for PL30, PL15 and PL45, indicating that PL30 was most vulnerable to Vp<sub>AHPND</sub>. The immune response of shrimp PL at this stage was robust, with Toll-like receptor (TLR), prophenoloxidase (proPO), lysozyme (lyso) and penaeidin (PEN) augmented approximately 10.7, 4.7, 6.5 and 3.2-fold, respectively. The expression initiated at one hour post-infection (h.p.i), peaked at 16 h.p.i and 20 h.p.i, and decreased at 18 h.p.i, indicating the crucial involvement of these immune related genes in the defence and recovery of the first-line defence mechanisms during Vp<sub>AHPND</sub> infection. This work also revealed that toxR gene represents a good indicator gene for <em>Vibrio</em> detection whereas PIR A, for Vp<sub>AHPND</sub> pathogenicity determination of <em>P. monodon</em>. Overall, these findings provided novel insights into the immune response and Vp<sub>AHPND</sub> susceptibility of different <em>P. monodon</em> PL stages during infection, with outcomes potentially useful in enhancing the application of health therapy and biosecured aquaculture practices to minimize the damaging risk of AHPND towards sustainable production of <em>P. monodon.</em>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Immune and bacterial toxin genes expression in different giant tiger prawn, <i>Penaeus monodon</i> post-larvae stages following AHPND-causing strain of <i>Vibrio parahaemolyticus</i> challenge","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Penaeus monodon; AHPND; PIR a; Immunity genes; Bacterial toxin gene","OtherDescriptors":null,"Notes":null,"AnaPub":2020,"MonPub":null,"DateUpdate":"2021-05-25","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000517752000014","VABBcode":null,"OpenAcc":1,"Handle":"10.1016/j.aqrep.2019.100248"},"refs":null,"anarec":{"AnaID":337968,"PubliDate":2020,"Pagination":"100248","XtraPublOfAnaID":null,"ISBN":null,"Volume":"16","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":329899,"SerRR":"Aquaculture Reports. 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