{"refrec":{"BRefID":338222,"RR":"<b>Naesens, L.; Bonnafous, P.; Agut, H.; De Clercq, E.</b> (2006). Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts. <i>Journal of Clinical Virology 37(S1)</i>: S69-S75. <a href=\"https://hdl.handle.net/10.1016/S1386-6532(06)70015-4\" target=\"_blank\">https://hdl.handle.net/10.1016/S1386-6532(06)70015-4</a>","BEntID":334848,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Journal of Clinical Virology 37(S1)</i>: S69-S75. <a href=\"https://hdl.handle.net/10.1016/S1386-6532(06)70015-4\" target=\"_blank\">https://hdl.handle.net/10.1016/S1386-6532(06)70015-4</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Naesens, L.; Bonnafous, P.; Agut, H.; De Clercq, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Naesens, L. <i>et al.</i>","Englishabstract":"Background: HHV-6 replication requires complex and poorly understood interactions between viral and cellular factors. Objectives: Several natural compounds or broad-acting pharmacological agents were studied in an attempt to discover new targets for anti-HHV-6 therapy. Study design: The antiviral activity was determined in human T-lymphoblasts, using HHV-6A (GS)-infected HSB-2 cells, HHV-6B (Z29)-infected MOLT-3 cells and HHV-6B (HST)-infected MT4 cells. Virus replication was measured by CPE and qPCR assay. Foscarnet was included as the reference compound. Results: Among the 15 natural compounds tested, only 'red marine algae' (an extract rich in sulfated polysaccharides) exhibited strong activity when added during virus adsorption. Among the broad-acting pharmacological agents, chloroquine, artemisinin, hypericin, ribavirin, resveratrol and glycyrrhizic acid were all inactive. Amantadine produced a reproducible inhibition of HHV-6 replication, albeit at relatively high concentrations. Except for lamotrigine, which was moderately active against HHV-6B, several antiepileptic drugs were shown to have no activity. We included several compounds which we previously described as potent HHV-6 inhibitors, i.e., the non-nucleoside inhibitor CMV423 and the acyclic nucleoside phosphonate analogues cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-3-deazaadenine. The latter compound exhibited remarkable anti-HHV-6 activity. Conclusion: Further optimization of compounds belonging to diverse classes of antiherpetic agents, for their specific action against HHV-6, is warranted.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"human herpesvirus 6; antiviral; CMV423; cidofovir; foscarnet","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2021-05-31","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000243845000015","VABBcode":null,"OpenAcc":0,"Handle":"10.1016/S1386-6532(06)70015-4"},"refs":null,"anarec":{"AnaID":338222,"PubliDate":2006,"Pagination":"S69-S75","XtraPublOfAnaID":null,"ISBN":null,"Volume":"37","Issue":"S1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":271565,"SerRR":"Journal of Clinical Virology. 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