{"refrec":{"BRefID":338233,"RR":"<b>Brahic, C.; Darro, F.; Belloir, M.; Bastide, J.; Kiss, R.; Delfourne, E.</b> (2002). Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine. <i>Bioorg. Med. Chem. 10(9)</i>: 2845-2853. <a href=\"https://hdl.handle.net/10.1016/S0968-0896(02)00148-7\" target=\"_blank\">https://hdl.handle.net/10.1016/S0968-0896(02)00148-7</a>","BEntID":334859,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Bioorg. Med. Chem. 10(9)</i>: 2845-2853. <a href=\"https://hdl.handle.net/10.1016/S0968-0896(02)00148-7\" target=\"_blank\">https://hdl.handle.net/10.1016/S0968-0896(02)00148-7</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Brahic, C.; Darro, F.; Belloir, M.; Bastide, J.; Kiss, R.; Delfourne, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Brahic, C. <i>et al.</i>","Englishabstract":"4-Substituted-7H-pyrido-[4,3,2-de][1,8] or [1,9]-phenanthroline-7-ones and 9-methyl-1,4-diazanaphtacene-3,10-dione, analogues of the marine pyridoacridine amphimedine were synthesised from isoquinoline-5,8-dione. The first compounds were obtained starting from a Diels–Alder reaction whereas the synthesis of the last compound was initiated by a reaction of condensation with 2-aminoacetophenone. The different tetra- and pentacyclic compounds were evaluated for in vitro cytotoxic activities against six distinct human cancer cell lines. 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