{"refrec":{"BRefID":33844,"RR":"<b>Devlin, C.L.</b> (2001). 5-Hydroxytryptamine stimulates net Ca<sup>2+</sup> flux in the ventricular muscle of a mollusc (<i>Busycon canaliculatum</i>) during cardioexcitation. <i>Biol. Bull. 200</i>: 344-350. <a href=\"https://dx.doi.org/10.2307/1543515\" target=\"_blank\">https://dx.doi.org/10.2307/1543515</a>","BEntID":33844,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Biol. Bull. 200</i>: 344-350. <a href=\"https://dx.doi.org/10.2307/1543515\" target=\"_blank\">https://dx.doi.org/10.2307/1543515</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Devlin, C.L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Devlin, C.L.","Englishabstract":"Noninvasive, self-referencing calcium (Ca<sup>2+</sup> ) electrodes were used to study the mechanisms by which 5-hydroxytryptamine (5-HT) affects net Ca<sup>2+</sup> flux across the sarcolemma of myocytes from ventricular trabeculae (from a marine gastropod, <i>Busycon canaliculatum</i>). Treat-ment of isolated trabeculae with 5-HT causes a net Ca<sup>2+</sup> efflux, which is 30% blocked by verapamil. These findings suggest that the efflux is in part the result of a previous Ca<sup>2+</sup> influx through L-type Ca<sup>2+</sup> channels and is due to a rapid Ca<sup>2+</sup> extrusion mechanism inherent to the sarcolemma of these myocytes. 5-HT-induced net Ca<sup>2+</sup> efflux is also reduced by about 40% by treatment with a sodium (Na 1 )-free, lithium (Li 1 )-substituted saline, which shuts down the Na-Ca exchanger during Ca<sup>2+</sup> extrusion. Cyclopiazonic acid (CPA), an inhibitor of the sarcoplasmic reticulum (SR) Ca<sup>2+</sup> ATPase, almost completely abolishes the 5-HT-in-duced net Ca<sup>2+</sup> efflux, suggesting that the SR rather than the extracellular pool is the primary Ca<sup>2+</sup> reservoir serving 5-HT-induced excitation.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"5-Hydroxytryptamine stimulates net Ca<sup>2+</sup> flux in the ventricular muscle of a mollusc (<i>Busycon canaliculatum</i>) during cardioexcitation","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-23 01:31:49.439118","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2001,"MonPub":null,"DateUpdate":"2003-04-03","DateCreate":"2003-04-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000169543000011","VABBcode":null,"OpenAcc":0,"DOI":"10.2307/1543515"},"refs":null,"anarec":{"AnaID":33844,"PubliDate":2001,"Pagination":"344-350","XtraPublOfAnaID":null,"ISBN":null,"Volume":"200","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42437,"SerRR":"The Biological Bulletin. Marine Biological Laboratory: Lancaster.  ISSN 0006-3185; e-ISSN 1939-8697","StandardTitleSer":"The Biological Bulletin","ISSN":"0006-3185","AbbrevSer":"Biol. Bull.","StandardTitleMon":null,"StartPage":344,"Pages":7,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Devlin","Firstname":"C. 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