{"refrec":{"BRefID":339289,"RR":"<b>Johansson, N.; Fredriksson, A.; Eriksson, P.</b> (2008). Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. <i>NeuroToxicology 29(1)</i>: 160-169. <a href=\"https://dx.doi.org/10.1016/j.neuro.2007.10.008\" target=\"_blank\">https://dx.doi.org/10.1016/j.neuro.2007.10.008</a>","BEntID":335924,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>NeuroToxicology 29(1)</i>: 160-169. <a href=\"https://dx.doi.org/10.1016/j.neuro.2007.10.008\" target=\"_blank\">https://dx.doi.org/10.1016/j.neuro.2007.10.008</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Johansson, N.; Fredriksson, A.; Eriksson, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Johansson, N.; Fredriksson, A.; Eriksson, P.","Englishabstract":"<a href=\"/topics/pharmacology-toxicology-and-pharmaceutical-science/perfluoro-compound\" title=\"Learn more about Perfluoro Compound from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">Perfluorinated compounds</a><span> (PFCs) are found in applications such oil/water repellents for clothing fabrics, carpets, food packaging, <a href=\"/topics/earth-and-planetary-sciences/lubricant\" title=\"Learn more about Lubricant from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">lubricants</a><span>, surfactants and <a href=\"/topics/earth-and-planetary-sciences/fire-extinguisher\" title=\"Learn more about Fire Extinguisher from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">fire extinguishers</a>. PFCs are persistent in the environment. They have been found in humans and in wildlife.</span></span></p><p>We reported earlier that persistent organic <a href=\"/topics/pharmacology-toxicology-and-pharmaceutical-science/pollutant\" title=\"Learn more about Pollutant from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">pollutants</a><span> (POPs), such as DDT, PCBs and BFRs, caused developmental neurotoxic defects in mice, manifested as persistent aberrations in spontaneous behaviour, habituation capability, learning and memory, and changes in the <a href=\"/topics/earth-and-planetary-sciences/cholinergics\" title=\"Learn more about Cholinergics from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">cholinergic</a> system in adults, when mice were exposed during a critical period of neonatal brain development.</span></p><p><!--  <span>The present study was conducted to see whether PFCs can cause similar developmental neurotoxic effects as earlier observed for POPs as PCBs and <a href=\"/topics/earth-and-planetary-sciences/pbde\" title=\"Learn more about PBDE from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">PBDEs</a>. NMRI male mice were exposed to a single-oral dose, either 1.4 or 21</span>&nbsp;<!--  μmol/kg body weight of PFOS (0.75 or 11.3<!--  &nbsp;<!--  mg), PFOA (0.58 or 8.70<!--  &nbsp;<!--  mg), or PFDA (0.72 or 10.8<!--  &nbsp;<!--  mg), via a metal gastric-tube at the age of 10 days. The control animals received in the same manner 10<!--  &nbsp;<!--  <span>ml/kg body weight of the 20% <a href=\"/topics/pharmacology-toxicology-and-pharmaceutical-science/lipid-emulsion\" title=\"Learn more about Lipid Emulsion from ScienceDirect's AI-generated Topic Pages\" class=\"topic-link\">fat emulsion</a> vehicle. Spontaneous behaviour (locomotion, rearing, and total activity), and habituation were observed in 2- and 4-month-old mice. The susceptibility of the cholinergic system was explored in a nicotine-induced spontaneous behaviour test in 4-month-old mice. Deranged spontaneous behaviour was observed in mice exposed to PFOS and PFOA, manifested as reduced and/or lack of habituation and hyperactivity in adult mice. These effects were also seen to worse with age. Neonatal exposure to PFOS and PFOA affected the cholinergic system, manifested as a hypoactive response to nicotine, compared to a hyperactive response to nicotine in controls. These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants.</span>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"PFC PFOS PFOA PFDA Developmental neurotoxicity Behaviour","OtherDescriptors":null,"Notes":null,"AnaPub":2008,"MonPub":null,"DateUpdate":"2021-06-24","DateCreate":"2021-06-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000253187600019","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.neuro.2007.10.008"},"refs":null,"anarec":{"AnaID":339289,"PubliDate":2008,"Pagination":"160-169","XtraPublOfAnaID":null,"ISBN":null,"Volume":"29","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":338481,"SerRR":"NeuroToxicology. Elsevier Science: Amsterdam.  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