{"refrec":{"BRefID":339478,"RR":"<b>EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Bampidis, V.; Azimonti, G.; de Lourdes Bastos, M.; Christensen, H.; Dusemund, B.; Kouba, M.; Kos Durjava, M.; López-Alonso, M.; López Puente, S.; Marcon, F.; Mayo, B.; Pechova, A.; Petkova, M.; Ramos, F.; Sanz, Y.; Villa, R.E.; Woutersen, R.; Glandorf, B.; Herman, L.; Maradona, M.P.; Saarela, M.; Tosti, L.; Anguita, M.; Galobart, J.; Holczknecht, O.; Manini, P.; Tarrés-Call, J.; Pettenati, E.; Pizzo, F.</b> (2019). Safety and efficacy of l‐histidine monohydrochloride monohydrate produced by fermentation with <i>Escherichia coli</i> (NITE BP‐02526) for all animal species. <i>EFSA Journal 17(8)</i>: e05785. <a href=\"https://dx.doi.org/10.2903/j.efsa.2019.5785\" target=\"_blank\">https://dx.doi.org/10.2903/j.efsa.2019.5785</a>","BEntID":336113,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>EFSA Journal 17(8)</i>: e05785. <a href=\"https://dx.doi.org/10.2903/j.efsa.2019.5785\" target=\"_blank\">https://dx.doi.org/10.2903/j.efsa.2019.5785</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Bampidis, V.; Azimonti, G.; de Lourdes Bastos, M.; Christensen, H.; Dusemund, B.; Kouba, M.; Kos Durjava, M.; López-Alonso, M.; López Puente, S.; Marcon, F.; Mayo, B.; Pechova, A.; Petkova, M.; Ramos, F.; Sanz, Y.; Villa, R.E.; Woutersen, R.; Glandorf, B.; Herman, L.; Maradona, M.P.; Saarela, M.; Tosti, L.; Anguita, M.; Galobart, J.; Holczknecht, O.; Manini, P.; Tarrés-Call, J.; Pettenati, E.; Pizzo, F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) <i>et al.</i>","Englishabstract":"Following a request from the European Commission, the Panel&nbsp;on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on <span class=\"smallCaps\">l</span>-histidine monohydrochloride monohydrate produced by fermentation with <i>Escherichia coli</i> (NITE BP-02526) when used as a nutritional additive or as a feed flavouring compound in feed and water for drinking for all animal species. The product under assessment is <span class=\"smallCaps\">l</span>-histidine HCl H<sub>2</sub>O produced by fermentation with a genetically modified strain of <i>E.&nbsp;coli</i> (NITE BP-02526). The production strain and its recombinant DNA were not detected in the final products. <span class=\"smallCaps\">l</span>-Histidine HCl H<sub>2</sub>O does not give rise to any safety concern to the production strain. The use of <span class=\"smallCaps\">l</span>-histidine HCl H<sub>2</sub>O is safe for the target species when used to supplement the diet in appropriate amounts. It is safe at the proposed use level of 25&nbsp;mg/kg when used as a flavouring compound for all animal species. The use of <span class=\"smallCaps\">l</span>-histidine HCl H<sub>2</sub>O in animal nutrition raises no safety concerns for consumers of animal products. The additive is not irritating to the skin or eyes and is not a skin sensitiser. There is a risk for persons handling the additive from the exposure to endotoxins by inhalation. The use of <span class=\"smallCaps\">l</span>-histidine as a feed additive does not represent a risk to the environment. The additive <span class=\"smallCaps\">l</span>-histidine HCl H<sub>2</sub>O is regarded as an effective source of the amino acid <span class=\"smallCaps\">l</span>-histidine when used as a nutritional additive. For the supplemental <span class=\"smallCaps\">l</span>-histidine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen. It is also considered efficacious as a feed flavouring compound under the proposed conditions of use.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Safety and efficacy of l‐histidine monohydrochloride monohydrate produced by fermentation with <i>Escherichia coli</i> (NITE BP‐02526) for all animal species","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2021-07-01","DateCreate":"2021-07-01","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000483892400007","VABBcode":null,"OpenAcc":1,"DOI":"10.2903/j.efsa.2019.5785"},"refs":null,"anarec":{"AnaID":339478,"PubliDate":2019,"Pagination":"e05785","XtraPublOfAnaID":null,"ISBN":null,"Volume":"17","Issue":"8","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":196342,"SerRR":"EFSA Journal. 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