{"refrec":{"BRefID":339687,"RR":"<b>Marasinghe Wadige, C.P.M.; Taylor, A.M.; Maher, W.A.; Ubrihien, R.P.; Krikowa, F.</b> (2014). Effects of lead-spiked sediments on freshwater bivalve, <i>Hyridella australis</i>: linking organism metal <i>exposure-dose-response</i>. <i>Aquat. Toxicol. 149</i>: 83-93. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2014.01.017\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2014.01.017</a>","BEntID":336322,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 149</i>: 83-93. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2014.01.017\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2014.01.017</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Marasinghe Wadige, C.P.M.; Taylor, A.M.; Maher, W.A.; Ubrihien, R.P.; Krikowa, F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Marasinghe Wadige, C.P.M. <i>et al.</i>","Englishabstract":"Lead entering aquatic ecosystems adsorbs to sediments and has the potential to cause adverse effects on the health of benthic organisms. To evaluate the freshwater bivalve <em>Hyridella australis</em> as a bioindicator for sediment toxicity, their <em>exposure-dose</em> and <em>response</em> to lead contaminated sediments (&lt; 0.01, 205&nbsp;±&nbsp;9 and 419&nbsp;±&nbsp;16&nbsp;μg/g dry mass) was investigated in laboratory microcosms using 28 day exposures. Despite high concentrations of lead in the sediments, organisms accumulated low concentrations of lead in their tissues after 28 days of exposure (low treatment: 2.2&nbsp;±&nbsp;0.2&nbsp;μg/g dry mass, high treatment: 4.2&nbsp;±&nbsp;0.1&nbsp;μg/g dry mass), however, accumulated lead concentrations in lead exposed organisms were two fold (low treatment) and four fold (high treatment) higher than that of unexposed organisms (1.2&nbsp;±&nbsp;0.3&nbsp;μg/g dry mass). Accumulation of lead by <em>H. australis</em> may have occurred as analogues of calcium and magnesium. Labial palps accumulated significantly more lead than other tissues. Of the lead accumulated in the hepatopancreas, 83%–91% was detoxified and stored in metal rich granules. The proportions and concentrations of lead in this fraction increased with lead exposure, which suggests that lead detoxification pathway plays an important role in metal tolerance of <em>H. australis</em>. The biologically active lead was mainly present in the mitochondrial fraction which increased with lead exposure. Total antioxidant capacity of <em>H. australis</em> significantly decreased while lipid peroxidation and lysosomal membrane destabilation increased with lead exposure. This study showed a clear lead <em>exposure-dose-response</em> relationship and indicates that <em>H. australis</em> would be a good biomonitor for lead in freshwater ecosystems.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Effects of lead-spiked sediments on freshwater bivalve, <i>Hyridella australis</i>: linking organism metal <i>exposure-dose-response</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-17 01:34:11.328431","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Biologically active lead; Biologically detoxified lead; Biomarkers; Hyridella australis; Oxidative stress; Sub-cellular partitioning","OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2021-07-06","DateCreate":"2021-07-06","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000334989300010","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2014.01.017"},"refs":null,"anarec":{"AnaID":339687,"PubliDate":2014,"Pagination":"83-93","XtraPublOfAnaID":null,"ISBN":null,"Volume":"149","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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