Document of bibliographic reference 339775

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Promising activities of marine natural products against hematopoietic malignancies

Abstract

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially available marine-derived compounds for the treatment of various hematopoietic cancers (e.g., leukemia and lymphoma), two molecules in clinical trials, and series of compounds and/or extracts from marine micro- and macroorganisms which have shown promising properties. In addition, the mechanisms of action of several active compounds and extracts are still unknown and require further study. The continuous upgrading of omics technologies has also allowed identifying enzymes with possible bioactivity (e.g., l-asparaginase is currently used for the treatment of leukemia) or the enzymes involved in the synthesis of bioactive secondary metabolites which can be the target of heterologous expression and genetic engineering.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000666707300001

Bibliographic citation

Saide, A.; Damiano, S.; Ciarcia, R.; Lauritano, C. (2021). Promising activities of marine natural products against hematopoietic malignancies. Biomedicines 9(6): 645. https://dx.doi.org/10.3390/biomedicines9060645

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true