Document of bibliographic reference 340007

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus

Abstract

The venom duct origins of predatory and defensive venoms has not been studied for hook-and-line fish hunting cone snails despite the pharmacological importance of their venoms. To better understand the biochemistry and evolution of injected predatory and defensive venoms, we compared distal, central and proximal venom duct sections across three specimens of C. striatus (Pionoconus) using proteomic and transcriptomic approaches. A total of 370 conotoxin precursors were identified from the whole venom duct transcriptome. Milked defensive venom was enriched with a potent cocktail of proximally expressed inhibitory α-, ω- and μ-conotoxins compared to milked predatory venom. In contrast, excitatory κA-conotoxins dominated both the predatory and defensive venoms despite their distal expression, suggesting this class of conotoxin can be selectively expressed from the same duct segment in response to either a predatory or defensive stimuli. Given the high abundance of κA-conotoxins in the Pionoconus clade, we hypothesise that the κA-conotoxins have evolved through adaptive evolution following their repurposing from ancestral inhibitory A superfamily conotoxins to facilitate the dietary shift to fish hunting and species radiation in this clade.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000670730700009

Bibliographic citation

Himaya, S.W.A.; Jin, A.-H.; Hamilton, B.; Rai, S.K.; Alewood, P.; Lewis, R.J. (2021). Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus. NPG Scientific Reports 11(1): 13282. https://dx.doi.org/10.1038/s41598-021-91919-4

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true