{"refrec":{"BRefID":340090,"RR":"<b>Yang, W.-S.; Qi, X.-R.; Xu, Q.-Z.; Yuan, C.-H.; Yi, Y.-H.; Tang, H.-F.; Shen, L.; Han, H.</b> (2021). A new sulfated triterpene glycoside from the sea cucumber <i>Colochirus quadrangularis</i>, and evaluation of its antifungal, antitumor and immunomodulatory activities. <i>Bioorg. Med. Chem. 41</i>: 116188. <a href=\"https://dx.doi.org/10.1016/j.bmc.2021.116188\" target=\"_blank\">https://dx.doi.org/10.1016/j.bmc.2021.116188</a>","BEntID":336725,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Bioorg. Med. Chem. 41</i>: 116188. <a href=\"https://dx.doi.org/10.1016/j.bmc.2021.116188\" target=\"_blank\">https://dx.doi.org/10.1016/j.bmc.2021.116188</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yang, W.-S.; Qi, X.-R.; Xu, Q.-Z.; Yuan, C.-H.; Yi, Y.-H.; Tang, H.-F.; Shen, L.; Han, H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yang, W.-S. <i>et al.</i>","Englishabstract":"Our continuing search for marine bioactive secondary metabolites led to the screening of crude extracts of sea cucumbers by the model of <i>Pyricularia oryzae</i>. A new sulfated triterpene glycoside, coloquadranoside A (1), together with four known triterpene glycosides, philinopside A, B, E and pentactaside B (2–5) were isolated from the sea cucumber <i>Colochirus quadrangularis</i>, and their structures were elucidated using extensive spectroscope analysis (ESI-MS, 1D and 2D NMR) and chemical methods. Coloquadranoside A possesses a 16-acetyloxy group in the holostane-type triterpene aglycone with a 7(8)–double bond, a double bond (25,26) at its side chain, and two β-D-xylose in the carbohydrate chain. Coloquadranoside A exhibits <i>in vitro</i> some antifungus, considerable cytotoxicity (IC50 of 0.46–2.03 μM) against eight human tumor cell lines, <i>in vivo</i> antitumor, and immunomodulatory activity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A new sulfated triterpene glycoside from the sea cucumber <i>Colochirus quadrangularis</i>, and evaluation of its antifungal, antitumor and immunomodulatory activities","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-14 01:31:59.895245","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Sea cucumber, Colochirus quadrangularis, Triterpene glycoside, Coloquadranoside A, Bioactivity","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-07-13","DateCreate":"2021-07-13","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000670094600007","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.bmc.2021.116188"},"refs":null,"anarec":{"AnaID":340090,"PubliDate":2021,"Pagination":"116188","XtraPublOfAnaID":null,"ISBN":null,"Volume":"41","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":258824,"SerRR":"Bioorganic & Medicinal Chemistry. 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