Document of bibliographic reference 340090
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities
- Abstract
- Our continuing search for marine bioactive secondary metabolites led to the screening of crude extracts of sea cucumbers by the model of Pyricularia oryzae. A new sulfated triterpene glycoside, coloquadranoside A (1), together with four known triterpene glycosides, philinopside A, B, E and pentactaside B (2–5) were isolated from the sea cucumber Colochirus quadrangularis, and their structures were elucidated using extensive spectroscope analysis (ESI-MS, 1D and 2D NMR) and chemical methods. Coloquadranoside A possesses a 16-acetyloxy group in the holostane-type triterpene aglycone with a 7(8)–double bond, a double bond (25,26) at its side chain, and two β-D-xylose in the carbohydrate chain. Coloquadranoside A exhibits in vitro some antifungus, considerable cytotoxicity (IC50 of 0.46–2.03 μM) against eight human tumor cell lines, in vivo antitumor, and immunomodulatory activity.
- WebOfScience code
- https://www.webofscience.com/wos/woscc/full-record/WOS:000670094600007
- Bibliographic citation
- Yang, W.-S.; Qi, X.-R.; Xu, Q.-Z.; Yuan, C.-H.; Yi, Y.-H.; Tang, H.-F.; Shen, L.; Han, H. (2021). A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. Bioorg. Med. Chem. 41: 116188. https://dx.doi.org/10.1016/j.bmc.2021.116188
- Topic
- Marine
- Is peer reviewed
- true
Authors
- author
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- Name
- Wen-Sheng Yang
- author
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- Name
- Xin-Rui Qi
- author
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- Name
- Qiang-Zhi Xu
- author
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- Name
- Chun-Hong Yuan
- author
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- Name
- Yang-Hua Yi
- author
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- Name
- Hai-Feng Tang
- author
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- Name
- Li Shen
- author
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- Name
- Hua Han