{"refrec":{"BRefID":34012,"RR":"<b>Murk, A.; Morse, D.; Boon, J.; Brouwer, A.</b> (1994). <i>In-vitro</i> metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver-microsomes of some wildlife species and rat. <i>Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 270(2-3)</i>: 253-261. <a href=\"https://dx.doi.org/10.1016/0926-6917(94)90069-8\" target=\"_blank\">https://dx.doi.org/10.1016/0926-6917(94)90069-8</a>","BEntID":34012,"PublicFlag":1,"CheckedFlag":0,"wosflag":0,"vabbflag":0,"RefStringPartII":". <i>Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 270(2-3)</i>: 253-261. <a href=\"https://dx.doi.org/10.1016/0926-6917(94)90069-8\" target=\"_blank\">https://dx.doi.org/10.1016/0926-6917(94)90069-8</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Murk, A.; Morse, D.; Boon, J.; Brouwer, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Murk, A. <i>et al.</i>","Englishabstract":"A qualitative study was performed of the capacity of hepatic microsomes of several wildlife species to metabolize 3,3',4,4'-tetrachlorobiphenyl (TCB). Hepatic microsomes of species environmentally exposed to polychlorinated biphenyls (PCBs): harbour porpoise (<i>Phocoena phocoena</i>), harbour seal (<i>Phoca vitulina</i>), common tern (<i>Sterna hirundo</i>), and hepatic microsomes from species experimentally exposed to PCBs: elder duck (<i>Somateria mollissima</i>), rainbow trout (<i>Salmo gairdneri</i>), flounder (<i>Platichthys flesus</i>), and Wistar rat, were incubated with <sup>14</sup>C-labelled TCB ([<sup>14</sup>C]TCB). The mammals and birds were able to metabolize TCB at a rate that correlated with their ethoxyresorufin-O-deethylase (EROD) activity. No [<sup>14</sup>C]TCB metabolism was observed in the fish, despite elevated EROD activity in the trout. HPLC analysis of diisopropylether extracts of the microsomal incubations indicated the presence of 4-OH-, 5-OH-, and 6-OH-tetrachlorobiphenyl metabolites and a yet unidentified metabolite. The ratio of the different hydroxy metabolites formed varied for the various species.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"<i>In-vitro</i> metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver-microsomes of some wildlife species and rat","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-14 01:31:05.874723","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1994,"MonPub":null,"DateUpdate":"2019-09-06","DateCreate":"2003-04-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1994NJ32700016","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/0926-6917(94)90069-8"},"refs":null,"anarec":{"AnaID":34012,"PubliDate":1994,"Pagination":"253-261","XtraPublOfAnaID":null,"ISBN":null,"Volume":"270","Issue":"2-3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45840,"SerRR":"European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section. Elsevier Science Publishers: Amsterdam; Lausanne; London; New York; Oxford; Shannon; Tokyo.  ISSN 0926-6917; e-ISSN 1878-6782","StandardTitleSer":"European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section","ISSN":"0926-6917","AbbrevSer":"Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. 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