{"refrec":{"BRefID":340125,"RR":"<b>Holzheimer, M.; Sinninghe Damste, J.S.; Schouten, S.; Havenith, R.W.A.; Minnaard, A.J.</b> (2021). Total synthesis of the alleged structure of crenarchaeol enables structure revision. <i>Angew. Chem. 133(32)</i>: 17645-17654. <a href=\"https://doi.org/10.1002/ange.202105384\" target=\"_blank\">https://doi.org/10.1002/ange.202105384</a>","BEntID":336760,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Angew. Chem. 133(32)</i>: 17645-17654. <a href=\"https://doi.org/10.1002/ange.202105384\" target=\"_blank\">https://doi.org/10.1002/ange.202105384</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Holzheimer, M.; Sinninghe Damste, J.S.; Schouten, S.; Havenith, R.W.A.; Minnaard, A.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Holzheimer, M. <i>et al.</i>","Englishabstract":"Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning lipid is undoubtedly the structurally most sophisticated of all known archaeal lipids and an iconic molecule in organic geochemistry. The 66-membered macrocycle possesses a unique chemical structure featuring 22 mostly remote stereocenters, and a cyclohexane ring connected by a single bond to a cyclopentane ring. Herein we report the first total synthesis of the proposed structure of crenarchaeol. 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