{"refrec":{"BRefID":34079,"RR":"<b>Hogstrand, C.; Grosell, M.; Wood, C.M.; Hansen, H.</b> (2003). Internal redistribution of radiolabelled silver among tissues of rainbow trout (<i>Oncorhynchus mykiss</i>) and European eel (<i>Anguilla anguilla</i>): the influence of silver speciation. <i>Aquat. Toxicol. 63(2)</i>: 139-157. <a href=\"https://dx.doi.org/10.1016/S0166-445X(02)00174-1\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(02)00174-1</a>","BEntID":34079,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 63(2)</i>: 139-157. <a href=\"https://dx.doi.org/10.1016/S0166-445X(02)00174-1\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(02)00174-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Hogstrand, C.; Grosell, M.; Wood, C.M.; Hansen, H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Hogstrand, C. <i>et al.</i>","Englishabstract":"Influence of water Ag(I) speciation on pharmacokinetics of Ag(I) during a post-exposure period was investigated in rainbow trout (<i>Oncorhynchus mykiss</i>) and European eel (<i>Anguilla anguilla</i>). The rainbow trout is sensitive to waterborne ionic Ag<sup>+</sup> whereas the eel is tolerant. The fish were acclimated to either of two chloride concentrations, 10 or 1200 µM, in synthetic soft water and then exposed to a sublethal 24-h pulse of 1.3 µg <sup>-1</sup> of <sup>110m</sup>Ag(I) added as <sup>110m</sup>AgNO<sub>3</sub> in these waters. The protocol provided exposures to mainly the free ion Ag<sup>+</sup> (low chloride water) or mainly AgCl<sub>aq</sub> (high chloride water). Contents and concentrations of <sup>110m</sup>Ag(I) in tissues and body fluids were then monitored over a 67-day post-exposure period in Ag(I)-free water of the same chloride levels. Changing the speciation of Ag(I) in the water had no effect on the whole body load of <sup>110m</sup>Ag(I), but did result in differences in internal distribution. In trout, changing water Ag(I) speciation significantly altered elimination or accumulation of Ag(I) in several body compartments. Notably, trout exposed to AgCl<sub>aq</sub> eliminated <sup>110m</sup>Ag(I) from the kidney more quickly than trout exposed to Ag(I) primarily as Ag<sup>+</sup>. This elimination was matched by higher concentrations of <sup>110m</sup>Ag in liver of trout exposed to Ag(I) primarily as AgCl<sub>aq</sub>. In eel, shifting speciation from Ag<sup>+</sup> to AgCl<sub>aq</sub> hastened elimination of <sup>110m</sup>Ag(I) from mid and posterior intestine and increased <sup>110m</sup>Ag(I) retention in kidney. While there was no difference between the two fish species in whole body <sup>110m</sup>Ag(I) load, most internal body compartments of trout had higher <sup>110m</sup>Ag(I) concentrations than those in eel early in the experiment. Because tissue-specific elimination times were longer in eel than in trout, these differences were generally cancelled by the end of the 67-day depuration period. The only exception was the liver, which in trout continued to accumulate <sup>110m</sup>Ag(I) throughout the experiment but in eel remained unchanged. The combined effect of <sup>110m</sup>Ag(I) movements in the two species was that trout retained all their accumulated <sup>110m</sup>Ag(I) through the 67-day period, whereas the body burden of <sup>110m</sup>Ag(I) in eel was reduced to half initial values by day 67.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Internal redistribution of radiolabelled silver among tissues of rainbow trout (<i>Oncorhynchus mykiss</i>) and European eel (<i>Anguilla anguilla</i>): the influence of silver speciation","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-04 01:30:50.804359","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":"Rainbow trout; European eel; Bioavailability; Pharmacokinetics","Notes":null,"AnaPub":2003,"MonPub":null,"DateUpdate":"2019-08-08","DateCreate":"2003-04-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000182028800005","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/S0166-445X(02)00174-1"},"refs":null,"anarec":{"AnaID":34079,"PubliDate":2003,"Pagination":"139-157","XtraPublOfAnaID":null,"ISBN":null,"Volume":"63","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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