{"refrec":{"BRefID":345091,"RR":"<b>Tenebro, C.P.; Von L. Trono, D.J.; Vicera, C.V.B.; Sabido, E.M.; Ysulat Jr, J.A.; Macaspac, A.J.M.; Tampus, K.A.; Fabrigar, T.A.P.; Saludes, J.P.; Dalisay, D.S.</b> (2021). Multiple strain analysis of <i>Streptomyces</i> species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities. <i>NPG Scientific Reports 11(1)</i>: 17544. <a href=\"https://dx.doi.org/10.1038/s41598-021-96886-4\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-021-96886-4</a>","BEntID":341726,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 11(1)</i>: 17544. <a href=\"https://dx.doi.org/10.1038/s41598-021-96886-4\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-021-96886-4</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tenebro, C.P.; Von L. Trono, D.J.; Vicera, C.V.B.; Sabido, E.M.; Ysulat Jr, J.A.; Macaspac, A.J.M.; Tampus, K.A.; Fabrigar, T.A.P.; Saludes, J.P.; Dalisay, D.S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tenebro, C.P. <i>et al.</i>","Englishabstract":"The marine ecosystem has become the hotspot for finding antibiotic-producing actinomycetes across the globe. Although marine-derived actinomycetes display strain-level genomic and chemodiversity, it is unclear whether functional traits, <i>i.e</i>., antibiotic activity, vary in near-identical <i>Streptomyces</i> species. Here, we report culture-dependent isolation, antibiotic activity, phylogeny, biodiversity, abundance, and distribution of <i>Streptomyces</i> isolated from marine sediments across the west-central Philippines. Out of 2212 marine sediment-derived actinomycete strains isolated from 11 geographical sites, 92 strains exhibited antibacterial activities against multidrug-resistant <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i>. The 16S rRNA and <i>rpoB</i> gene sequence analyses confirmed that antibiotic-producing strains belong to the genus <i>Streptomyces</i>, highlighting <i>Streptomyces parvulus</i> as the most dominant species and three possible new species. Antibiotic-producing <i>Streptomyces</i> strains were highly diverse in Southern Antique, and species diversity increase with marine sediment depth. Multiple strains with near-identical 16S rRNA and <i>rpoB</i> gene sequences displayed varying strength of antibiotic activities. The genotyping of PKS and NRPS genes revealed that closely related antibiotic-producing strains have similar BGC domains supported by their close phylogenetic proximity. These findings collectively suggest <i>Streptomyces</i>' intraspecies adaptive characteristics in distinct ecological niches that resulted in outcompeting other bacteria through differential antibiotic production.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Multiple strain analysis of <i>Streptomyces</i> species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-30 01:31:56.779344","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-09-20","DateCreate":"2021-09-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000702017500040","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-021-96886-4"},"refs":null,"anarec":{"AnaID":345091,"PubliDate":2021,"Pagination":"17544","XtraPublOfAnaID":null,"ISBN":null,"Volume":"11","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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