{"refrec":{"BRefID":347390,"RR":"<b>Kolora, S.R.J.; Owens, G.L.; Vazquez, J.M.; Stubbs, A.; Chatla, K.; Jainese, C.; Seeto, K.; McCrea, M.; Sandel, M.W.; Vianna, J.A.; Maslenikov, K.; Bachtrog, D.; Orr, J.W.; Love, M.; Sudmant, P.H.</b> (2021). Origins and evolution of extreme life span in Pacific Ocean rockfishes. <i>Science (Wash.) 374(6569)</i>: 842-847. <a href=\"https://dx.doi.org/10.1126/science.abg5332\" target=\"_blank\">https://dx.doi.org/10.1126/science.abg5332</a>","BEntID":344082,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Science (Wash.) 374(6569)</i>: 842-847. <a href=\"https://dx.doi.org/10.1126/science.abg5332\" target=\"_blank\">https://dx.doi.org/10.1126/science.abg5332</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kolora, S.R.J.; Owens, G.L.; Vazquez, J.M.; Stubbs, A.; Chatla, K.; Jainese, C.; Seeto, K.; McCrea, M.; Sandel, M.W.; Vianna, J.A.; Maslenikov, K.; Bachtrog, D.; Orr, J.W.; Love, M.; Sudmant, P.H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kolora, S.R.J. <i>et al.</i>","Englishabstract":"Pacific Ocean rockfishes (genus Sebastes) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-lived taxa and 137 longevity-associated genes with direct effects on life span through insulin signaling and with pleiotropic effects through size and environmental adaptations. A genome-wide screen of structural variation reveals copy number expansions in the immune modulatory butyrophilin gene family in long-lived species. The evolution of different rockfish life histories is coupled to genetic diversity and reshapes the mutational spectrum driving segregating CpG→TpG variants in long-lived species. These analyses highlight the genetic innovations that underlie life history trait adaptations and, in turn, how they shape genomic diversity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Origins and evolution of extreme life span in Pacific Ocean rockfishes","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-30 01:31:57.248133","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-11-18","DateCreate":"2021-11-18","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000717915400030","VABBcode":null,"OpenAcc":0,"DOI":"10.1126/science.abg5332"},"refs":null,"anarec":{"AnaID":347390,"PubliDate":2021,"Pagination":"842-847","XtraPublOfAnaID":null,"ISBN":null,"Volume":"374","Issue":"6569","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43776,"SerRR":"Science (Washington). 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