{"refrec":{"BRefID":347418,"RR":"<b>Palacios-Ortega, J.; García-Linares, S.; Rivera-de-Torre, E.; Heras-Márquez, D.; Gavilanes, J.G.; Slotte, J.P.; Martínez-del-Pozo, A.</b> (2021). Structural foundations of sticholysin functionality. <i>Biochimica et Biophysica Acta-Proteins and Proteomics 1869(10)</i>: 140696. <a href=\"https://dx.doi.org/10.1016/j.bbapap.2021.140696\" target=\"_blank\">https://dx.doi.org/10.1016/j.bbapap.2021.140696</a>","BEntID":344110,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Biochimica et Biophysica Acta-Proteins and Proteomics 1869(10)</i>: 140696. <a href=\"https://dx.doi.org/10.1016/j.bbapap.2021.140696\" target=\"_blank\">https://dx.doi.org/10.1016/j.bbapap.2021.140696</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Palacios-Ortega, J.; García-Linares, S.; Rivera-de-Torre, E.; Heras-Márquez, D.; Gavilanes, J.G.; Slotte, J.P.; Martínez-del-Pozo, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Palacios-Ortega, J. <i>et al.</i>","Englishabstract":"Actinoporins constitute a family of α pore-forming toxins produced by sea anemones. The soluble fold of these proteins consists of a β-sandwich flanked by two α-helices. Actinoporins exert their activity by specifically recognizing sphingomyelin at their target membranes. Once there, they penetrate the membrane with their N-terminal α-helices, a process that leads to the formation of cation-selective pores. These pores kill the target cells by provoking an osmotic shock on them.In this review, we examine the role and relevance of the structural features of actinoporins, down to the residue level. We look at the specific amino acids that play significant roles in the function of actinoporins and their fold. Particular emphasis is given to those residues that display a high degree of conservation across the actinoporin sequences known to date. In light of the latest findings in the field, the membrane requirements for pore formation, the effect of lipid composition, and the process of pore formation are also discussed.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Structural foundations of sticholysin functionality","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"actinoporins; structure-function relationship; lipid membranes","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-11-29","DateCreate":"2021-11-18","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000680177100004","VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.bbapap.2021.140696"},"refs":null,"anarec":{"AnaID":347418,"PubliDate":2021,"Pagination":"140696","XtraPublOfAnaID":null,"ISBN":null,"Volume":"1869","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":264462,"SerRR":"Biochimica et Biophysica Acta-Proteins and Proteomics. 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